Favorable prognostic impact of Natural Killer cells and T cells in high-grade serous ovarian carcinoma
| Autor: | Frede Donskov, Karina Dahl Steffensen, Jon Røikjær Henriksen, Marianne Waldstrøm, Mette Hjortkjær, Christina Braad Petersen, Anders Jakobsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Time Factors
Neutrophils CD8 Antigens Denmark Cell Count GPI-Linked Proteins B7-H1 Antigen 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine CD57 Antigens Lymphocytes Tumor-Infiltrating Antigen Immunity Antigens CD Ovarian carcinoma medicine Image Processing Computer-Assisted Cytotoxic T cell Humans Radiology Nuclear Medicine and imaging In patient Cystadenocarcinoma Aged Ovarian Neoplasms Immunity Cellular business.industry Hematology General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry Cystadenocarcinoma Serous Killer Cells Natural Serous fluid Oncology 030220 oncology & carcinogenesis Cancer research Female Neoplasm Grading business Cell Adhesion Molecules T-Lymphocytes Cytotoxic |
| Zdroj: | Henriksen, J R, Donskov, F, Waldstrøm, M, Jakobsen, A, Hjortkjaer, M, Petersen, C B & Dahl Steffensen, K 2020, ' Favorable prognostic impact of Natural Killer cells and T cells in high-grade serous ovarian carcinoma ', Acta Oncologica, vol. 59, no. 6, pp. 652-659 . https://doi.org/10.1080/0284186X.2019.1711173 |
| DOI: | 10.1080/0284186X.2019.1711173 |
| Popis: | Introduction: The aim of the present study was to investigate the prognostic impact of intratumoral cytotoxic T cells, Natural Killer (NK) cells, neutrophils and PD-L1 expression in patients with epithelial ovarian cancer. Methods: All patients diagnosed with high-grade serous carcinoma (HGSC) in Denmark in 2005 were included in the study. Immunohistochemical staining for PD-L1, CD8, CD66b and CD57 was performed on tumor tissue from 283 patients. Cell densities were analyzed using a digital image analysis method. The primary endpoint was overall survival (OS). Results: The median OS for HGSC patients was 30 months. It was 45 months in patients with high level of CD57+ NK cells (≥10 cells/mm 2) compared with 29 month in patients with low level (2) (p =.0310). The median OS was 37 and 25 months in patients with high vs. low level of CD8+ T cells (cutoff 80 cells/mm 2) (p =.0008). In multivariate analysis, high numbers of CD57+ NK cells and CD8+ T cells remained independent markers of favorable OS, adjusted hazard ratio (HR) 0.67; p =.041, and HR 0.72; p =.020, respectively. PD-L1 expression was associated with improved OS (37 months vs. 22 months, p =.0006), but was only borderline significant in the multivariate analysis (HR 0.77, p =.061). CD66b + neutrophils had no association with OS. Conclusions: In patients with HGSC tumor-infiltrating CD57+ NK cells and CD8+ T cells had favorable prognostic impact, while PD-L1 expression had borderline favorable prognostic significance. CD66b + neutrophils had no prognostic association. These findings may influence future immunotherapy development. |
| Databáze: | OpenAIRE |
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