Microrheology, microcirculation and structural compensatory mechanisms of a chronic kidney disease rat model. A preliminary study
| Autor: | Barbara Barath, László Horváth, Adam Deak, Tamás Lesznyák, Norbert Nemeth, Souleiman Ghanem, Balazs Szabo, Maitham Nasser, László Bidiga, Bence Tanczos, Laszlo Fazekas, Katalin Peto |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Physiology medicine.medical_treatment 030204 cardiovascular system & hematology Erythrocyte aggregation 030218 nuclear medicine & medical imaging Microcirculation Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine medicine Animals Renal Insufficiency Chronic Kidney business.industry Hematology medicine.disease Pathophysiology Nephrectomy Rats Disease Models Animal medicine.anatomical_structure Endocrinology Hemorheology Female Hemoglobin Cardiology and Cardiovascular Medicine business Rheology Kidney disease |
| Zdroj: | Clinical hemorheology and microcirculation. 75(1) |
| ISSN: | 1875-8622 |
| Popis: | Background Chronic kidney disease (CKD) models are known to study pathophysiology and various treatment methods. Renal dysfunction could influence erythrocytes through several pathways. However, hemorheological and microcirculatory relation of CKD models are not completely studied yet. Objective To evaluate erythrocyte micro-rheology, microcirculatory and structural compensatory mechanisms in a rat model of CKD. Methods Female Sprague-Dawley rats were subjected to nephrectomy group (NG, n = 6) or sham-operated group (SG, n = 6). NG rats were subjected to 5/6 nephrectomy in two stages. In SG no intervention was made on kidneys. Hemorheological and hematological measurements were carried out after each stage, and 5 weeks after the last operation. Histological and microcirculatory studies were done on the remaining kidney and compared with sham rats. Results Serum creatinine increased in NG (p = 0.008), accompanied with decrease of red blood cell count (p = 0.028) and hemoglobin (p = 0.015). Erythrocyte aggregation parameters slightly increased in NG, while the elongation index didn't show significant changes. Microcirculation was intact in the remnant kidney of NG. However, in comparison with SG, the diameter of glomeruli increased significantly (p Conclusions Erythrocyte mass was influenced more than micro-rheological properties in this model. The main compensation mechanism was rather structural than at microcirculatory level. |
| Databáze: | OpenAIRE |
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