Brain metastases with an unknown primary: a clinical perspective
| Autor: | Rebecca McDermot, Gordon E. Catton, Libni Eapen, Lee Gerig, Bhavani D. Nair, Cyril Danjoux, Mylene Vachet, David J. Stewart, Andre Girard, Paul Genest |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Neurology medicine.medical_treatment Autopsy Complete resection Actuarial Analysis Biopsy medicine Humans In patient Aged medicine.diagnostic_test business.industry Brain Neoplasms Subtotal Resection Middle Aged Surgery Radiation therapy Oncology Unknown primary Neoplasms Unknown Primary Female Neurology (clinical) business |
| Zdroj: | Journal of neuro-oncology. 6(1) |
| ISSN: | 0167-594X |
| Popis: | A review of 43 patients with cerebral metastases, an unknown primary, and no other sites of metastases is presented. 27/43 (62.7%) had solitary metastases and 37.2% (16/43) had multiple metastases. Surgical treatment involved complete resection in 30.2%, subtotal resection in 37.2% and biopsy alone or no surgical procedure in the remainder. 39/43 patients underwent whole brain irradiation with the majority receiving 3,000-4,000 rads/10-20 fractions. Overall survival was 52% at six months and 20% at one year, and was significantly better in patients with solitary as opposed to multiple metastases (p less than 0.03). A failure analysis including autopsy data demonstrates that (28/41) 68.3% of patients died of progressive intracranial disease without extracerebral metastases. Implications for treatment strategies are discussed. |
| Databáze: | OpenAIRE |
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