Effect of vitamin E supplementation on carbogen-induced amelioration of noise induced hearing loss in man

Autor: Sharma Rk, W. Selvamurthy, Radhey Shyam, Kumar Vyonkesh Mani, Ambika Prasad Singh, Neeru Kapoor
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Male
Antioxidant
medicine.medical_treatment
audiometry
medicine.disease_cause
chemistry.chemical_compound
oxidative stress
Vitamin E
biology
Malondialdehyde
lcsh:Otorhinolaryngology
Glutathione
lcsh:RF1-547
Military Personnel
Noise
Occupational
lcsh:Industrial medicine. Industrial hygiene
Antioxidant enzymes
carbogen
Noise-induced hearing loss
Adult
malondialdehyde
medicine.medical_specialty
total antioxidant status
Nitric Oxide
Superoxide dismutase
Speech and Hearing
lcsh:RC963-969
Carbogen
Internal medicine
Administration
Inhalation
medicine
Humans
occupational noise
Analysis of Variance
Superoxide Dismutase
Public Health
Environmental and Occupational Health
Carbon Dioxide
medicine.disease
Surgery
Oxygen
Endocrinology
Otorhinolaryngology
chemistry
Hearing Loss
Noise-Induced
Dietary Supplements
biology.protein
noise induced hearing loss
Oxidative stress
Blood Chemical Analysis
Zdroj: Noise and Health, Vol 13, Iss 55, Pp 452-458 (2011)
ISSN: 1998-4030
1463-1741
Popis: The study explores the effect of occupational noise on oxidative stress status and prophylactic effect of Vitamin E and carbogen (5% CO 2 +95%O 2 ) breathing in alleviating the oxidative damage and conserving the hearing in human volunteers exposed to intense occupational noise. Plasma total antioxidant status, blood glutathione (GSH), malondialdehyde (MDA), antioxidant enzyme activities of GSH peroxidase (EC 1.11.1.9, GPx), superoxide dismutase (EC 1.15.1.1; SOD) in erythrocytes, nitric oxide and nitric oxide synthase in plasma were assessed before and after 6 days of administration of Vitamin E and Carbogen. Results of the study indicate that the exposure to noise for 6 days increased blood concentration of MDA, decreased concentrations of reduced GSH, antioxidant enzyme activity of SOD and plasma total antioxidant status in control (noise) group. Vitamin E- supplemented group showed decline in oxidative stress reflected by significant decrease in blood concentration of MDA and increase in antioxidant enzyme activity of erythrocyte SOD. Results of audiometric studies revealed that breathing of carbogen prevented the development of temporary threshold shift; thereby reducing the risk of noise induced hearing loss.
Databáze: OpenAIRE
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