A molecular view on paranodal junctions of myelinated fibers
| Autor: | Catherine Faivre-Sarrailh, Laurence Goutebroze, Natalia Denisenko-Nehrbass, Jean-Antoine Girault |
|---|---|
| Přispěvatelé: | Institut du Fer à Moulin (IFM - Inserm U1270 - SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU) |
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
MESH: Axons
Molecular composition [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology MESH: Membrane Glycoproteins Biology MESH: Neuropeptides Nerve Fibers Myelinated 03 medical and health sciences Myelin 0302 clinical medicine Physiology (medical) Axonal membrane Ranvier's Nodes medicine Transmembrane glycoprotein Animals Humans MESH: Animals Axon 030304 developmental biology 0303 health sciences Membrane Glycoproteins MESH: Humans General Neuroscience Neuropeptides Ranvier node Intracellular Membranes Axolemma Axons Cell biology MESH: Nerve Fibers Myelinated MESH: Extracellular Space MESH: Intracellular Membranes medicine.anatomical_structure nervous system MESH: Ranvier's Nodes Extracellular Space 030217 neurology & neurosurgery Intracellular |
| Zdroj: | Journal of Physiology-Paris Journal of Physiology-Paris, Elsevier, 2002, 96 (1-2), pp.99-103. ⟨10.1016/s0928-4257(01)00085-7⟩ |
| ISSN: | 0928-4257 |
| DOI: | 10.1016/s0928-4257(01)00085-7⟩ |
| Popis: | International audience; The axoglial paranodal junctions, flanking the Ranvier nodes, are specialized adhesion sites between the axolemma and myelinating glial cells. Unraveling the molecular composition of paranodal junctions is crucial for understanding the mechanisms involved in the regulation of myelination, and positioning and segregation of the voltage-gated Na+ and K+ channels, essential for the generation and conduction of action potentials. Paranodin/Caspr was the first neuronal transmembrane glycoprotein identified at the paranodal junctions. Paranodin/Caspr is associated on the axonal membrane with contactin/F3, a glycosylphosphatidylinositol-anchored protein, essential for its correct targeting. The extra and intracellular regions of paranodin encompass multiple domains which can be involved in protein-protein interactions with other axonal proteins and glial proteins. Thus, paranodin plays a central role in the assembly of multiprotein complexes necessary for the formation and maintenance of paranodal junctions. |
| Databáze: | OpenAIRE |
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