Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?
| Autor: | Anish Suri, Matteo G. Levisetti, Emil R. Unanue |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
T-Lymphocytes
Immunology Antigen presentation Epitopes T-Lymphocyte Autoimmunity Peptide binding Major histocompatibility complex Article Mice Antigen MHC class I Animals Humans Insulin Immunology and Allergy Antigen Presentation biology Antigen processing Histocompatibility Antigens Class I Diabetes Mellitus Type 1 Biochemistry T cell selection biology.protein Peptides Sequence motif |
| Zdroj: | Current Opinion in Immunology. 20:105-110 |
| ISSN: | 0952-7915 |
| Popis: | One seminal aspect in autoimmune diabetes is antigen presentation of beta cell antigens by the diabetes-propensity class II histocompatibility molecules. The binding properties of I-Ag7 molecules are reviewed here and an emphasis is placed on their selection of peptides with a highly specific sequence motif, in which one or more acidic amino acids are found at the carboxy end interacting at the P9 anchoring site of I-Ag7. The reasons for the central role of I-Ag7 in the autoimmune response are analyzed. The insulin B chain segment 9-23 is a hot spot for T cell selection and a striking example of a weak MHC binding peptide that triggers autoreactivity. |
| Databáze: | OpenAIRE |
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