Metabolic and Acid-Base Changes Following Acute Cholinesterase Inhibition
| Autor: | Armand J. Gold, John M. Weller, Gustave Freeman |
|---|---|
| Rok vydání: | 1957 |
| Předmět: |
medicine.medical_specialty
chemistry.chemical_element Alkalies Artificial respiration Phosphates chemistry.chemical_compound Organophosphate Poisoning Physiology (medical) Internal medicine medicine Humans Respiratory system Cholinesterase Acid-Base Equilibrium Parathion biology Phosphorus Metabolic acidosis Hypoxia (medical) medicine.disease Lactic acid Endocrinology Respiratory failure chemistry biology.protein Cholinesterase Inhibitors medicine.symptom |
| Zdroj: | American Journal of Physiology-Legacy Content. 188:321-326 |
| ISSN: | 0002-9513 |
| DOI: | 10.1152/ajplegacy.1957.188.2.321 |
| Popis: | Dogs acutely intoxicated with the cholinesterase inhibitors, Parathion or Sarin, develop both respiratory and metabolic acidosis. The former results from respiratory failure and the latter probably from tissue oxygen deprivation secondary to circulatory failure aggravated by an accelerated oxygen demand due to cholinergic stimulation. Accumulation of lactic acid accounts for about half of the metabolic acidosis. Plasma inorganic phosphorus, potassium and glucose become elevated but only the phosphorus rise persists during concomitant artificial respiration. Hypoxia resulting from circulatory insufficiency appears to be a major factor in the shift of phosphorus and potassium from the cells. Excessive release of adrenaline is probably primarily responsible for hyperglycemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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