Relationships of thigh muscle contractile and non-contractile tissue with function, strength, and age in boys with Duchenne muscular dystrophy
| Autor: | Krista Vandenborne, Hiroshi Akima, H. Lee Sweeney, Roxanna M. Bendixen, Glenn A. Walter, Sean Germain, Claudia R. Senesac, Ishu Arpan, Donovan J. Lott, Jasjit Deol |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
musculoskeletal diseases
Male Adolescent Duchenne muscular dystrophy Thigh Biceps Article medicine Humans Muscle Strength Muscular dystrophy Child Muscle Skeletal Genetics (clinical) medicine.diagnostic_test business.industry Disease progression Thigh muscle Age Factors Magnetic resonance imaging Anatomy medicine.disease Magnetic Resonance Imaging Muscular Dystrophy Duchenne medicine.anatomical_structure Neurology Lower Extremity Torque Pediatrics Perinatology and Child Health Disease Progression Neurology (clinical) medicine.symptom business Muscle contraction Muscle Contraction |
| Popis: | The purpose of this study was to assess the contractile and non-contractile content in thigh muscles of patients with Duchenne muscular dystrophy (DMD) and determine the relationship with functional abilities. Magnetic resonance images of the thigh were acquired in 28 boys with DMD and 10 unaffected boys. Muscle strength, timed functional tests, and the Brookes Lower Extremity scale were also assessed. Non-contractile content in the DMD group was significantly greater than in the control group for six muscles, including rectus femoris, biceps femoris-long head and adductor magnus. Non-contractile content in the total thigh musculature assessed by MRI correlated with the Brookes scale (r(s)=0.75) and supine-up test (r(s)=0.68), as well as other functional measures. An age-related specific torque increase was observed in the control group (r(s)=0.96), but not the DMD (r(s)=0.06). These findings demonstrate that MRI measures of contractile and non-contractile content can provide important information about disease progression in DMD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|