Circulating and tissue biomarkers as predictors of bromine gas inhalation

Autor:	David A. Ford, Duha Aishah, Aftab Ahmad, Shama Ahmad, Aamir Ahmad, Shazia Shakil, Charity J. Morgan, Louis J. Dell'Italia, Juan Xavier Masjoan Juncos
Rok vydání:	2020
Předmět:	Male 0301 basic medicine medicine.medical_specialty 030204 cardiovascular system & hematology Lung injury Gastroenterology Article General Biochemistry Genetics and Molecular Biology Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine History and Philosophy of Science Internal medicine Troponin I Heart rate Animals Medicine Chemical Warfare Agents Lung chemistry.chemical_classification Inhalation Exposure medicine.diagnostic_test business.industry Myocardium General Neuroscience Fatty Acids Fatty acid Bromine Hydrocarbons Brominated Rats Pulse oximetry 030104 developmental biology Bronchoalveolar lavage medicine.anatomical_structure chemistry Toxicity business Biomarkers
Zdroj:	Ann N Y Acad Sci
ISSN:	1749-6632 0077-8923
Popis:	The threat from deliberate or accidental exposure to halogen gases is increasing as is their industrial application and use as chemical warfare agents. Biomarkers that can identify halogen exposure, diagnose victims of exposure or predict injury severity, and enable appropriate treatment are lacking. We conducted these studies to determine and validate biomarkers of bromine (Br(2)) toxicity and correlate the symptoms and the extent of cardiopulmonary injuries. Unanesthetized rats were exposed to Br(2) and monitored noninvasively for clinical scores and pulse oximetry. Animals were euthanized and grouped at various time intervals to assess brominated fatty acid (BFA) content in the plasma, lung, and heart using mass spectrometry. Bronchoalveolar lavage fluid (BALF) protein content was used to assess pulmonary injury. Cardiac troponin I (cTnI) was assessed in the plasma to evaluate cardiac injury. The blood, lung, and cardiac tissue BFA content significantly correlated with the clinical scores, tissue oxygenation, heart rate, and cardiopulmonary injury parameters. Total (free + esterified) bromostearic acid levels correlated with lung injury as indicated by BALF protein content and free bromostearic acid levels correlated with plasma cTNI levels. Thus, BFAs and cardiac injury biomarkers can identify Br(2) exposure and predict the severity of organ damage.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb61620fe0fe420b1fb22768a841bfa3 https://doi.org/10.1111/nyas.14422 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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