Evaluation of 11-β hydroxysteroid dehydrogenase type 1 in cutaneous fibroblasts cultures of psoriatic lesional skin before and after narrow band-UVB phototherapy
| Autor: | Linda Tognetti, Paola Marcolongo, Giancarlo Mariotti, Michele Pellegrino, Elisa Cinotti, Emanuele Trovato, Camilla Marrocco, Pietro Rubegni, Francesco Damiani |
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| Rok vydání: | 2021 |
| Předmět: |
endocrine system
medicine.medical_specialty Erythema Immunology Dehydrogenase Inflammation Endogeny Dermatology Skin Diseases Internal medicine 11-beta-Hydroxysteroid Dehydrogenase Type 1 medicine Immunology and Allergy Humans Psoriasis Radiology Nuclear Medicine and imaging 11β-HSD1 plaque psoriasis chemistry.chemical_classification nbUVB phototherapy integumentary system Adrenal cortex human skin cultures Fibroblasts Ultraviolet Therapy General Medicine 11 β hydroxysteroid dehydrogenase Enzyme medicine.anatomical_structure Endocrinology chemistry medicine.symptom Cortisone hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Photodermatology, photoimmunologyphotomedicine. 38(4) |
| ISSN: | 1600-0781 |
| Popis: | The endogenous glucocorticoids (eGCs) group include those molecules, similar to exogenous synthetic ones in terms of chemical structure, which are synthesised in the human body: the largest amount is produced by the adrenal cortex and the rest by the skin, with a slower process. The known eCGs effects in the skin include epidermal thinning, melanogenesis impairment, inflammation suppression and erythema reduction.1-2 Cortisol is the most important among eGCs and its availability depends on the pre-receptorial regulation of the 11β-hydroxysteroid Dehydrogenase (HSD) enzymes, i.e.: 11β-HSD1 (converts cortisone to the active form, cortisol; 11β-HSD2 (catalyses the opposite reaction). |
| Databáze: | OpenAIRE |
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