A VLSI field-programmable mixed-signal array to perform neural signal processing and neural modeling in a prosthetic system

Autor: Aryeh H. Taub, Roni Hogri, Ivan Herreros, Simeon A. Bamford, Paul F. M. J. Verschure, Matti Mintz, P. Del Giudice, Andrea Giovannucci
Rok vydání: 2012
Předmět:
Computer science
Conditioning
Classical
Models
Neurological
Biomedical Engineering
Context (language use)
02 engineering and technology
User-Computer Interface
03 medical and health sciences
0302 clinical medicine
Cerebellum
0202 electrical engineering
electronic engineering
information engineering
Internal Medicine
Electronic engineering
Animals
Computer Simulation
Brain–computer interface
Very-large-scale integration
Signal processing
Blinking
business.industry
General Neuroscience
020208 electrical & electronic engineering
Rehabilitation
Classical conditioning
Electroencephalography
Signal Processing
Computer-Assisted
Mixed-signal integrated circuit
Equipment Design
Prostheses and Implants
Extinction (psychology)
Switched capacitor
Electric Stimulation
Rats
Equipment Failure Analysis
business
030217 neurology & neurosurgery
Computer hardware
Zdroj: IEEE Transactions on Neural Systems and Rehabilitation Engineering
ISSN: 1558-0210
1534-4320
DOI: 10.1109/TNSRE.2012.2187933
Popis: A very-large-scale integration field-programmable mixed-signal array specialized for neural signal processing and neural modeling has been designed. This has been fabricated as a core on a chip prototype intended for use in an implantable closed-loop prosthetic system aimed at rehabilitation of the learning of a discrete motor response. The chosen experimental context is cerebellar classical conditioning of the eye-blink response. The programmable system is based on the intimate mixing of switched capacitor analog techniques with low speed digital computation; power saving innovations within this framework are presented. The utility of the system is demonstrated by the implementation of a motor classical conditioning model applied to eye-blink conditioning in real time with associated neural signal processing. Paired conditioned and unconditioned stimuli were repeatedly presented to an anesthetized rat and recordings were taken simultaneously from two precerebellar nuclei. These paired stimuli were detected in real time from this multichannel data. This resulted in the acquisition of a trigger for a well-timed conditioned eye-blink response, and repetition of unpaired trials constructed from the same data led to the extinction of the conditioned response trigger, compatible with natural cerebellar learning in awake animals.
Databáze: OpenAIRE
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