Plasma TIMP-1 and CEA in detection of primary colorectal cancer: a prospective, population based study of 4509 high-risk individuals
| Autor: | Knud Thygesen, Nils Brünner, Ute Hoyer, Gerard J. Davis, Hans B Rahr, Petra Stieber, Barry L. Dowell, Ib Jarle Christensen, Jesper V. Olsen, Søren Laurberg, Lars N. Jorgensen, Marinus A. Blankenstein, Hans Jørgen Nielsen |
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| Přispěvatelé: | Laboratory Medicine, CCA - Disease profiling |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Colorectal cancer Colonoscopy Gastroenterology Young Adult Carcinoembryonic antigen Risk Factors Internal medicine medicine Clinical endpoint Humans Prospective Studies Young adult Prospective cohort study neoplasms Early Detection of Cancer Aged Aged 80 and over Tissue Inhibitor of Metalloproteinase-1 biology medicine.diagnostic_test business.industry Cancer Sigmoidoscopy Middle Aged medicine.disease digestive system diseases Carcinoembryonic Antigen biology.protein Female Colorectal Neoplasms business Biomarkers |
| Zdroj: | Scandinavian Journal of Gastroenterology, 46(1), 60-69. Informa Healthcare Nielsen, H J, Brunner, N, Jorgensen, L N, Olsen, J, Rahr, H B, Thygesen, K, Hoyer, U, Laurberg, S, Stieber, P, Blankenstein, M A, Davis, G, Dowell, B L & Christensen, I J 2011, ' Plasma TIMP-1 and CEA in detection of primary colorectal cancer: a prospective, population based study of 4509 high-risk individuals ', Scandinavian Journal of Gastroenterology, vol. 46, no. 1, pp. 60-69 . https://doi.org/10.3109/00365521.2010.513060 Nielsen, H J, Brünner, N, Jorgensen, L N, Olsen, J, Rahr, H B, Thygesen, K, Hoyer, U, Laurberg, S, Stieber, P, Blankenstein, M A, Davis, G, Dowell, B L, Christensen, I J & Danish Endoscopy Study Group on Colorectal Cancer Detection 2011, ' Plasma TIMP-1 and CEA in detection of primary colorectal cancer : a prospective, population based study of 4509 high-risk individuals ', Scandinavian Journal of Gastroenterology. Supplement, vol. 46, no. 1, pp. 60-9 . https://doi.org/10.3109/00365521.2010.513060 Nielsen, H J, Brünner, N, Jorgensen, L N, Olsen, J, Rahr, H B, Thygesen, K, Hoyer, U, Laurberg, S, Stieber, P, Blankenstein, M A, Davis, G, Dowell, B L, Christensen, I J & Danish Endoscopy Study Group on Colorectal Cancer Detection 2011, ' Plasma TIMP-1 and CEA in detection of primary colorectal cancer: a prospective, population based study of 4509 high-risk individuals ', Scandinavian Journal of Gastroenterology, vol. 46, no. 1, pp. 60-9 . https://doi.org/10.3109/00365521.2010.513060 |
| ISSN: | 0036-5521 |
| Popis: | Objective. The combination of plasma tissue inhibitor of metalloproteinases-1 (TIMP-1) and carcinoembryonic antigen (CEA) may be valuable biomarkers for early detection of colorectal cancer (CRC). A prospective, population based study was performed to validate this hypothesis. Material and methods. Individuals (n = 4509) referred for large bowel endoscopy due to symptoms of CRC were prospectively included. Baseline data and concurrent diseases were recorded. The primary endpoint was detection of CRC and findings at examinations were recorded using International Classification of Diseases-10 codes. Plasma was obtained before endoscopy and TIMP-1 and CEA levels were determined after the inclusion of all individuals. Results. Findings were based on sigmoidoscopy in 1766 and colonoscopy in 2743 individuals. Colon cancer (CC) was detected in 184 and rectal cancer in 110 individuals. Ten individuals with other cancers, 856 with adenomas and 1176 with non-neoplastic findings were also detected. The biomarker levels were increased in a variety of diseases including CRC compared to individuals without any findings at endoscopy. A multivariable analysis demonstrated that both markers were significant and independent detectors of CRC. Combining both biomarkers, independent contributions from each (TIMP-1, odds ratio (OR) = 1.8 (95% confidence interval (CI): 1.4-2.2), p = 5 ng/ml, OR = 2.3, 95% CI: 1.9-2.7 (p |
| Databáze: | OpenAIRE |
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