In vivo and in vitro degradation of a novel bioactive guided tissue regeneration membrane
| Autor: | Erkki Wuolijoki, Jaakko Keranen, Tuomo Nieminen, Ilkka Kallela, Heikki Kainulainen, Ilmari Hiidenheimo, Immo Rantala |
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| Rok vydání: | 2006 |
| Předmět: |
Time Factors
Absorption of water Polyglycolide Inherent viscosity Biocompatible Materials Mandible chemistry.chemical_compound In vivo Animals Medicine Dental Implants Sheep business.industry Regeneration (biology) Dental Implantation Endosseous Membranes Artificial Anatomy In vitro Biodegradation Environmental Membrane Otorhinolaryngology chemistry Guided Tissue Regeneration Periodontal Biophysics Degradation (geology) Female Surgery Oral Surgery business |
| Zdroj: | International Journal of Oral and Maxillofacial Surgery. 35:727-732 |
| ISSN: | 0901-5027 |
| Popis: | The aim of this study was to assess degradation of a novel bioactive guided tissue regeneration (GTR) membrane and to quantify the concurrent tissue responses. Pieces of membrane composed of poly-l-lactide, poly-d,l-lactide, trimethylenecarbonate and polyglycolide were dipped into an N-methyl-2-pyrroline (NMP) solution and implanted in the mandibles of 10 sheep. The animals were sacrificed at 6-104 weeks. Parallel in vitro degradation was analysed by measuring the inherent viscosity, water absorption and remaining mass. One of the 2 in vitro sets of membranes was prehandled with NMP. At 6-26 weeks in vivo, the gradually more degraded implants were surrounded by a fibrous network. At 52 and 104 weeks, the implants and fibrous networks were non-detectable. Foreign body granulomatous reactions were not observed. In vitro, the mass of the NMP-exposed membranes diminished linearly over the 2-year period down to 10%, while the non-NMP-exposed membrane maintained all their mass for the first 16 weeks. The membranes without NMP had absorbed significantly less water at weeks 4 and 8 than the other group. The inherent viscosity decreased relatively uniformly in the in vitro groups. In conclusion, the in vivo degradation was complete in 12 months with only mild histologic responses; the degradation in vitro may be slower. NMP accelerates the degradation. |
| Databáze: | OpenAIRE |
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