Collagen Binding of Staphylococcus aureus Is a Virulence Factor in Experimental Endocarditis
| Autor: | Anders Heimdahl, Jan-Ingmar Flock, Torgny Schennings, Stefan A. Hienz |
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| Rok vydání: | 1996 |
| Předmět: |
Integrins
Staphylococcus aureus Receptors Collagen Time Factors Micrococcaceae Mutant Virulence medicine.disease_cause Virulence factor Microbiology medicine Animals Humans Immunology and Allergy Endocarditis Rats Wistar biology Strain (chemistry) Fibrinogen Endocarditis Bacterial Gene Expression Regulation Bacterial Staphylococcal Infections biology.organism_classification medicine.disease Fibronectins Rats Disease Models Animal Infectious Diseases Infective endocarditis Female Collagen Endothelium Vascular |
| Zdroj: | Journal of Infectious Diseases. 174:83-88 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/174.1.83 |
| Popis: | The role of Staphylococcus aureus collagen binding in the development of experimental endocarditis was studied. Two isogenic strains of S. aureus, 1 carrying an insertional inactivation of the gene encoding collagen-binding protein, were compared in a rat model of catheter-induced infective endocarditis (i.e.). Separate groups of rats with traumatized aortic valves were intravenously challenged with 1 of the strains. In rats sacrificed 24 h after inoculation, the collagen-binding strain significantly outnumbered the mutant strain (P < .001); however, 1 h after challenge, there was no difference in numbers of the 2 strains. The results were substantiated, using a 1:1 mixture of the parent strain and the mutant as an inoculate. Our findings suggest that collagen binding of S. aureus is important in the sustenance of experimental IE and plays a limited role during the initial attachment of the microorganism to traumatized aortic valves. |
| Databáze: | OpenAIRE |
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