Epileptic seizures in cerebral venous sinus thrombosis: Subgroup analysis of VENOST study
| Autor: | Birsen Ince, Serkan Demir, Seden Demirci, Hamit Genc, Hakan Ekmekçi, Hesna Bektas, Gülnur Tekgöl Uzuner, Bijen Nazliel, Taskin Gunes, Nevzat Uzuner, Uygar Utku, Taskin Duman, Ozge Yilmaz Kusbeci, Nilgun Cinar, Mustafa Bakar, Hakan Tekeli, Ahmet Tufekci, Nida Tascilar, Ali Yavuz Karahan, Derya Uluduz, Vedat Ali Yürekli, Hayriye Kucukoglu, Dilek Necioglu Orken, Eylem Ozaydin Goksu, Nilufer Yesilot, Mustafa Acikgoz, Ipek Midi, Hasan Hüseyin Kozak, Arda Yilmaz, Mustafa Gokce, Mehmet Ali Sungur, Hale Zeynep Batur Caglayan, Firdevs Ezgi Ucan Tokuc, Sena Colakoglu, Nazire Afsar, Necdet Mengulluoglu, Serdar Oruc, Yüksel Kablan, Ufuk Aluclu, Baki Göksan, Fatih Ozdag, Aysel Milanlioglu, Mehmet Yaman, Murat Cabala, Osman Özgür Yalın, Fusun Mayda Domac, Vildan Yayla, Cemile Handan Misirli, Başak Karakurum Göksel, Hatice Kurucu, Sevim Baybaş, Şerefnur Öztürk, Sevki Sahin, Mehmet Güney Şenol, Emrah Aytaç |
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| Přispěvatelé: | Uluduz, Derya, Midi, Ipek, Duman, Taskin, Yayla, Vildan, Karahan, Ali Yavuz, Afsar, Nazire, Goksu, Eylem Ozaydin, Mengulluoglu, Necdet, Aytac, Emrah, Sungur, Mehmet Ali, Yesilot, Nilufer, Ince, Birsen, Yalin, Osman Ozgur, Oruc, Serdar, Senol, Mehmet Guney, Yilmaz, Arda, Gokce, Mustafa, Demirci, Seden, Kusbeci, Ozge Yilmaz, Uzuner, Gulnur, Caglayan, Hale Zeynep Batur, Acikgoz, Mustafa, Kurucu, Hatice, Ozdag, Fatih, Baybas, Sevim, Ekmekci, Hakan, Cabala, Murat, Yaman, Mehmet, Yurekli, Vedat Ali, Tekeli, Hakan, Genc, Hamit, Utku, Uygar, Sahin, Sevki, Tokuc, Firdevs Ezgi Ucan, Uzuner, Nevzat, Bektas, Hesna, Kablan, Yuksel, Goksel, Basak Karakurum, Milanlioglu, Aysel, Orken, Dilek Necioglu, Aluclu, Ufuk, Colakoglu, Sena, Tufekci, Ahmet, Bakar, Mustafa, Nazliel, Bijen, Tascilar, Nida, Goksan, Baki, Kozak, Hasan Huseyin, Demir, Serkan, Misirli, Cemile Handan, Kucukoglu, Hayriye, Cinar, Nilgun, Domac, Fusun Mayda, Ozturk, Serefnur, Gunes, Taskin, Maltepe Üniversitesi, Tıp Fakültesi, [Belirlenecek], Acibadem University Dspace, Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı., EKN-8251-2022 |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Neurologic disease Pediatrics Focal neurologic deficit Oral contraceptive agent Cerebral venous sinus thrombosis Cerebral hemorrhage Epilepsy 0302 clinical medicine Observational study Middle aged Cerebrovascular disease Priority journal Medical parameters Brain radiography General Medicine Brain hemorrhage Prognosis Seizure Thrombosis Multicenter study Clinical trial Nuclear magnetic resonance imaging Retrospective study PUERPERIUM PREGNANCY Neurology Brain vein Clinical neurology Cohort Cerebral infarction Subgroup analysis Female Cohort analysis Infection Sinus thrombosis intracranial Brain infarction Human Adult medicine.medical_specialty Family history Early seizure Neuroimaging Consciousness disorders Major clinical study Neurosciences & neurology Pathophysiology Article Cortical vein 03 medical and health sciences Magnetic resonance imaging Age Seizures medicine Humans In patient Prospective study Demography Disease duration Cerebral Sinus Thrombosis Vein Thrombosis Superior Sagittal Sinus Consciousness disorder business.industry Neurosciences Methodology VEIN Gender Anticonvulsive agent medicine.disease Retrospective studies Malignant neoplasm SSS Clinical feature Sagittal sinus thrombosis Cerebral sinus thrombosis RISK-FACTORS Risk factor Neurology (clinical) business Prospective studies Controlled study Complication 030217 neurology & neurosurgery |
| Popis: | Çalışmada 38 yazar bulunmaktadır. Bu yazarlardan sadece Bursa Uludağ Üniversitesi mensuplarının girişleri yapılmıştır. Purpose: The aim of this study is to evaluate the presence and prognostic impact of early seizures in cerebral venous sinus thrombosis patients (CVST). Method: VENOST is a retrospective and prospective national multicenter observational study. CVST patients with or without epileptic seizures (ES) were analyzed and compared in terms of demographic and imaging data, causative factors, clinical variables, and prognosis in a total of 1126 patients. Results: The mean age of the patients in the ES group was 39.73 +/- 12.64 and 40.17 +/- 14.02 years in the non-ES group (p > 0.05). Epileptic seizures were more common (76.6 %) in females (p < 0.001). Early ES occurred in 269 of 1126 patients (23.9 %). Epileptic seizures mainly presented in the acute phase (71.4 %) of the disease (p < 0.001). Majority of these (60.5 %) were in the first 24 h of the CVST. The most common neurological signs were focal neurologic deficits (29.9 %) and altered consciousness (31.4 %) in the ES group. Superior sagittal sinus (SSS) and cortical veins (CV) involvement were the most common sites of thrombosis and the mostly related etiology were found puerperium in seizure group (30.3 % vs 13.9 %). Patients with seizures had worse outcome in the first month of the disease (p < 0.001) but these did not have any influence thereafter. Conclusions: In this largest CVST cohort (VENOST) reported female sex, presence of focal neurological deficits and altered consciousness, thrombosis of the SSS and CVs, hemorrhagic infarction were risk factors for ES occurrence in patients with CVST. |
| Databáze: | OpenAIRE |
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