Antioxidant and Synergistic Antidiabetic Activities of a Three-Plant Preparation Used in Cameroon Folk Medicine
| Autor: | Francine Tankeu Nzufo, Marcel Azabji Kenfack, Constant Anatole Pieme, Pauline Nanfack, Vicky Jocelyne Ama Moor, Bruno Moukette Moukette, Jeanne Ngogang, Cacral Prosper Biapa Nya |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Antioxidant Article Subject DPPH medicine.medical_treatment 01 natural sciences Glibenclamide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Diabetes mellitus medicine Sida rhombifolia Traditional medicine biology Triglyceride business.industry Glutathione medicine.disease Streptozotocin biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Endocrinology chemistry business 030217 neurology & neurosurgery medicine.drug Research Article |
| Zdroj: | International Scholarly Research Notices |
| ISSN: | 2356-7872 |
| Popis: | Introduction. Several plant preparations like a mixture of aqueous extracts of Spilanthes africana; Portulaca oleracea; and Sida rhombifolia are currently utilized in Foumban (West Cameroon) to manage diabetes. The aim of this study is to investigate the antidiabetic property of the aqueous mixture of three plant extracts (1 : 1 : 1) on streptozotocin induced diabetes rats. Methods. Diabetes was induced to rats by intraperitoneal (i.p.) injection of streptozotocin (STZ) at a dose of 50 mg/kg b.w. The diabetic rats received different dosages of the mixture of extracts for 21 days and glibenclamide 6.5 mg/kg b.w. as positive control. Results. The results showed that the mixture of extracts significantly (p<0.05) decreased the level of the glycaemia, the total cholesterol, triglyceride, and LDL-cholesterol as well as MDA, AST, ALT, and creatinine levels. It also increased significantly the concentration of HDL-cholesterol, glutathione, and TAOS. A great reduction of the atherogenic indexes CT/HDL and LDL/HDL of the treated groups was observed. Each extract and the mixture demonstrated significant scavenging property on DPPH and OH radicals and present a good antioxidant property. Conclusion. The mixture of plant extracts has hypoglycemic, antioxidant, and hypolipidemic properties and can be used for the management of diabetes mellitus. |
| Databáze: | OpenAIRE |
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