Effects of an activator and an inhibitor of protein kinase C on serotonin receptors induced by rat brain mRNA in Xenopus oocytes
| Autor: | M. Matsumoto, E.A. Barnard |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Serotonin
medicine.medical_specialty Xenopus Kainate receptor Fluorides Xenopus laevis chemistry.chemical_compound Chlorides Sphingosine Internal medicine medicine Animals RNA Messenger Aluminum Compounds Phorbol 12 13-Dibutyrate Protein Kinase C Protein kinase C 5-HT receptor Kainic Acid biology Activator (genetics) General Neuroscience Electric Conductivity Brain biology.organism_classification Molecular biology Rats Enzyme Activation Endocrinology chemistry Receptors Serotonin Oocytes Signal transduction |
| Zdroj: | Neuroscience Letters. 167:183-186 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(94)91057-x |
| Popis: | The effects of bath-applied phorbol esters, protein kinase C (PKC) activators, and sphingosine, a PKC inhibitor, on membrane currents evoked by serotonin were studied in Xenopus oocytes injected with rat brain mRNA. The oscillatory Cl − current in response to bath-applied 50 nM serotonin was significantly depressed by 200 nM phorbol dibutyrate and remarkably augmented by 100 μM sphingosine. Both drugs have little effect either on the nonspecific Cl − current response induced by aluminum fluoride or on the cationic current response induced by 1 mM kainate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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