A Luminescent and Biocompatible PhotoCORM
| Autor: | Peter C. Ford, Alessia Pallaoro, Agustin E. Pierri, Guang Wu |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Tris
Luminescence Cell Survival Phosphines chemistry.chemical_element Context (language use) Photochemistry Biochemistry Catalysis Bipyridine chemistry.chemical_compound 2 2'-Dipyridyl Colloid and Surface Chemistry Coordination Complexes Cell Line Tumor Fluorescence microscope Humans Moiety Hydroxymethyl Carbon Monoxide Luminescent Agents General Chemistry Rhenium Photochemical Processes chemistry Phosphine |
| Zdroj: | Journal of the American Chemical Society. 134:18197-18200 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja3084434 |
| Popis: | The water-soluble rhenium(I) complex fac-[Re(bpy)(CO)(3)(thp)](+) (1) [CF(3)SO(3)(-) salt; bpy = 2,2'-bipyridine, thp = tris(hydroxymethyl)phosphine] is both strongly luminescent and photoactive toward carbon monoxide release. It is stable in aerated aqueous media, is incorporated into cells from the human prostatic carcinoma cell line PPC-1, and shows no apparent cytotoxicity. Furthermore, the solvated Re(I) photoproduct of CO release (2) is also luminescent, a feature that allows one to track the transformation of 1 to 2 inside such cells using confocal fluorescence microscopy. In this context, 1 is a very promising candidate as a photoactivated CO releasing moiety (photoCORM) with potential therapeutic applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|