Improving the Cure Rate of Alarm Treatment for Monosymptomatic Nocturnal Enuresis by Increasing Bladder Capacity—A Randomized Controlled Trial in Children
| Autor: | Kim Bernaerts, Veronique Vandermaelen, Jan D. van Gool, An Bael, Herbert Hirche, Hildegard Lax, Koen J. Van Hoeck |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
biology business.industry Urology Urinary system Medizin Urinary incontinence Placebo biology.organism_classification law.invention Surgery Randomized controlled trial Enuresis law Tasa Anesthesia medicine Human medicine medicine.symptom Oxybutynin Prospective cohort study business medicine.drug |
| Zdroj: | The journal of urology |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1016/j.juro.2007.10.096 |
| Popis: | Purpose We prospectively assessed response and cure rates of alarm treatment, following pretreatment with antimuscarinics and/or holding exercises aimed at increasing maximum volume voided in 149 children with monosymptomatic nocturnal enuresis. Materials and Methods In a prior trial the same 149 children had been randomized into 5 groups to assess interventions for increasing maximum volume voided, namely placebo or antimuscarinics with (groups A and B, respectively) and without (C and D, respectively) holding exercises, and a control group (E) receiving just alarm treatment. Following pretreatment groups A to D received alarm treatment. Full response and cure rates were assessed, as well as the influence on these rates of baseline maximum volume voided, increase in maximum volume voided after pretreatment, gender, age and previous treatment. Results Neither full response nor cure was influenced significantly by the increase in maximum volume voided achieved in groups A and B with holding exercises. Overall full response ranged from 50% to 73%, and overall cure ranged from 50% to 67%. Possible predictors for full response and cure were prior treatment (p |
| Databáze: | OpenAIRE |
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