No Observable Correlation between Central Nervous System Side Effects and EFV Plasma Concentrations in Japanese HIV Type 1-Infected Patients Treated with EFV Containing HAART
| Autor: | Masaaki Takahashi, Naoto Mamiya, Shiro Ibe, Naoya Okumura, Tsuguhiro Kaneda, Motohiro Hamaguchi, Tatsuo Suzuki, Yuichi Kudaka, Atsushi Hirano |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Central Nervous System Cyclopropanes Male medicine.medical_specialty Efavirenz Anti-HIV Agents Immunology Central nervous system HIV Infections Gastroenterology chemistry.chemical_compound Japan Acquired immunodeficiency syndrome (AIDS) Antiretroviral Therapy Highly Active Virology Immunopathology Internal medicine medicine Humans Sida biology business.industry Middle Aged Viral Load biology.organism_classification medicine.disease Rash Benzoxazines CD4 Lymphocyte Count Infectious Diseases medicine.anatomical_structure chemistry Alkynes HIV-1 Female Viral disease medicine.symptom business Viral load |
| Zdroj: | AIDS Research and Human Retroviruses. 23:983-987 |
| ISSN: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.2006.0193 |
| Popis: | The present study assessed the relationship between central nervous system (CNS) side effects and plasma concentrations of efavirenz (EFV) in Japanese HIV-1-infected patients. Subjects consisted of 69 HIV-1-infected patients (57 therapy-naive and 12 therapy-experienced patients) being treated using EFV in combination with other antiretroviral agents at the outpatient HIV clinic. Successful virological treatment was achieved in 61 patients. Eight patients discontinued EFV containing therapy because CNS symptoms did not resolve (four patients), EFV-specific mutations were detected (two patients), or skin rash was observed (two patients). Mean EFV plasma concentration for 61 effectively treated patients, measured at 15 h postdosing, was 2.42 microg/ml (range: 0.78-6.82 microg/ml). This EFV concentration range contributed to suppressed viral load in these Japanese patients. Adverse CNS effects were observed in 19 patients soon after therapy onset. These effects disappeared within 1 month except for four patients who suffered severe CNS side effects. Mean EFV plasma concentrations were not significantly different between subjects with (2.45 +/- 1.08 microg/ml) and without (2.42 +/- 1.40 microg/ml) CNS side effects. We concluded no correlation existed between the plasma EFV concentration and the emergence of CNS side effects in Japanese HIV-1-infected patients. Further investigations, enforced with the drug concentration measurement at earlier time points and more appropriate assessment of CNS symptoms, are required. |
| Databáze: | OpenAIRE |
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