Association between coronary artery vitamin D receptor expression and select systemic risks factors for coronary artery atherosclerosis
| Autor: | Thomas C. Register, David M. O’Sullivan, R Xie, P F Schnatz, Jay R. Kaplan, Thomas B. Clarkson, Xuezhi Jiang, Matthew Nudy, S.E. Appt |
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| Rok vydání: | 2021 |
| Předmět: |
Vitamin
medicine.medical_specialty Inflammation Coronary Artery Disease Anterior Descending Coronary Artery Calcitriol receptor chemistry.chemical_compound Risk Factors Internal medicine medicine Vitamin D and neurology Humans Vitamin D Cholesterol business.industry Obstetrics and Gynecology General Medicine Atherosclerosis medicine.disease Menopause medicine.anatomical_structure Endocrinology chemistry Receptors Calcitriol Female medicine.symptom business Artery |
| Zdroj: | Climacteric. 25:369-375 |
| ISSN: | 1473-0804 1369-7137 |
| Popis: | OBJECTIVE The aim of this study is to analyze the association between coronary artery vitamin D receptor (VDR) expression and systemic coronary artery atherosclerosis (CAA) risk factors. METHODS Female cynomolgus monkeys (n = 39) consumed atherogenic diets containing the women's equivalent of 1000 IU/day of vitamin D3. After 32 months consuming the diets, each monkey underwent surgical menopause. After 32 postmenopausal months, CAA and VDR expression were quantified in the left anterior descending coronary artery. Plasma 25OHD3, lipid profiles and serum monocyte chemotactic protein-1 (MCP-1) were measured. RESULTS In postmenopausal monkeys receiving atherogenic diets, serum MCP-1 was significantly elevated compared with baseline (482.2 ± 174.2 pg/ml vs. 349.1 ± 163.2 pg/ml, respectively; p |
| Databáze: | OpenAIRE |
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