Comparison of Polyphenol Profile and Antimutagenic and Antioxidant Activities in Two Species Used as Source of Solidaginis herba - Goldenrod
| Autor: | Krzysztof Domaradzki, Adam Matkowski, Andrzej Dryś, Dorota Woźniak, Sylwester Ślusarczyk |
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| Rok vydání: | 2018 |
| Předmět: |
Flavonoid
Quinic Acid Bioengineering Solidago canadensis 01 natural sciences Biochemistry Antioxidants chemistry.chemical_compound Structure-Activity Relationship Flavonols Picrates Species Specificity Kaempferols Molecular Biology chemistry.chemical_classification biology Traditional medicine Dose-Response Relationship Drug 010405 organic chemistry Plant Extracts Biphenyl Compounds Antimutagenic Agents General Chemistry General Medicine biology.organism_classification Quercitrin 0104 chemical sciences Solidago 010404 medicinal & biomolecular chemistry chemistry Phytochemical Polyphenol Mutagenesis Molecular Medicine Quercetin Lipid Peroxidation Kaempferol |
| Zdroj: | Chemistrybiodiversity. 15(4) |
| ISSN: | 1612-1880 |
| Popis: | European Pharmacopoeia accepts two equivalent species Solidago canadensis L. and S. gigantea Ait. as Goldenrod (Solidaginis herba). We compared phytochemical profile of both species from invasive populations in Poland. Further, we compared in vitro antimutagenic and antioxidant activities of solvent extracts from aerial (AP) and underground parts (UP). In S. gigantea, flavonoid profile was dominated by quercetin glycosides, with quercitrin as the major compound. In S. canadensis, quercetin and kaempferol rutinosides were two major constituents. Caffeoylquinic acids (CQAs) were less diverse with 5-CQA as a main compound. In UP, over 20 putative diterpenoids were detected, mostly unidentified. Several CQAs were present in higher amounts than in AP. Antioxidant and antimutagenic activities were different between species and organs, with the strongest inhibition of lipid peroxidation by ether and ethyl acetate fractions from AP of both species (IC50 13.33-16.89 μg/mL) and butanol fraction from S. gigantea UP (IC50 = 13.32 μg/mL). Chemical mutagenesis was completely inhibited by non-polar fractions, but oxidative mutagenesis was inhibited up to 35% only by S. canadensis. No clear relationship was found between chemical profiles and antimutagenic activity. In conclusion, both species have diverse activity and their phytochemical profiles should be considered in quality evaluation. UP of these weeds can also provide potential chemopreventive substances for further studies. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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