Mitochondrial uptake of bridged bis-methylpyridinium aldoximes and induction of the 'petite' phenotype in yeast
| Autor: | Guy Dodin, Dietrich Averbeck, Sylvano Nocentini, Pierre Demerseman, Jacques Dupont |
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| Rok vydání: | 1991 |
| Předmět: |
Cellular respiration
Stereochemistry Saccharomyces cerevisiae Biophysics Pyridinium Compounds Biology Mitochondrion Biochemistry DNA Mitochondrial Membrane Potentials chemistry.chemical_compound Oxygen Consumption Methylene Methylpyridinium Molecular Biology Electrochemical potential Cell Biology biology.organism_classification Yeast In vitro Hydrocarbons Mitochondria Kinetics Phenotype chemistry DNA Damage |
| Zdroj: | Biochemical and biophysical research communications. 179(2) |
| ISSN: | 0006-291X |
| Popis: | The 3, 3′-[ω,ω′-alkanediylbis(oxy)]bis[2-(hydroxyimino)methyl]-1-methylpyridinium derivatives bearing a linking chain of 4, 5 and 6 methylene groups are accumulated in mitochondria with increasing efficiency under the effect of the electrical potential. Accumulation does not take place with derivatives carrying a 2 and 3 methylene-long linking chain. The uptake process is saturable. The efficiency of the various derivatives to induce the “petite” phenotype in yeast reflects the uptake rate observed with purified mitochondria. |
| Databáze: | OpenAIRE |
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