Mononuclear Cell Infiltrate and Hla-Dr Expression in 28 Pituitary Adenomas
| Autor: | Margaret M. Esiri, Hugh B. Coakham, L. Havas, M. L. Rossi, M al Izzi, N. R. Jones |
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| Rok vydání: | 1990 |
| Předmět: |
Adenoma
Cancer Research Pathology medicine.medical_specialty medicine.drug_class T-Lymphocytes Cell Biology Monoclonal antibody Peripheral blood mononuclear cell 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Immune system Antigen HLA-DQ Antigens medicine HLA-DR Humans Pituitary Neoplasms Frozen section procedure Macrophages HLA-DR Antigens General Medicine medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis CD8 |
| Zdroj: | Tumori Journal. 76:543-547 |
| ISSN: | 2038-2529 0300-8916 |
| Popis: | Frozen sections from 28 pituitary adenomas were reacted with a panel of monoclonal antibodies to macrophages, lymphocytes and HLA-Dr invariant chain. A low number of macrophages were demonstrated in all tumors, mainly perivascular. CD8 and CD4 lymphocytes were detected in even smaller numbers in 80% and 14% of tumors respectively. B lymphocytes were present in only 1 case. An occasional NK cell was present in 1/13 cases studied. HLA-Dr antigen was expressed by macrophages in all cases and by tumor cells in 2 growth hormone-producing adenomas/19 adenomas. These findings may represent evidence for a low degree of cellular immune response to pituitary adenomas. |
| Databáze: | OpenAIRE |
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