Langerhans cell histiocytosis of the thyroid complicated by papillary thyroid carcinoma: A case report and brief literature review
| Autor: | Shi Chen, Xin Wu, Li-yang Zhang, Ya-ping Luo, Ying Jiang, Rui-e Feng |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty endocrine system endocrine system diseases Lymph node biopsy 030209 endocrinology & metabolism Thyroid carcinoma surgery 03 medical and health sciences 0302 clinical medicine Langerhans cell histiocytosis medicine Humans Thyroid Neoplasms Clinical Case Report Thyroid cancer medicine.diagnostic_test business.industry Thyroid Carcinoma General Medicine medicine.disease Thyroid Diseases Carcinoma Papillary Histiocytosis Histiocytosis Langerhans-Cell Fine-needle aspiration medicine.anatomical_structure Chemotherapy Adjuvant Thyroid Cancer Papillary 030220 oncology & carcinogenesis papillary thyroid carcinoma Differential diagnosis business Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Rationale: Langerhans cell histiocytosis (LCH) involves mainly the skin and bone and rarely the thyroid. Meanwhile, papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer. Both LCH and PTC could make the thyroid enlarged and hypermetabolic. The coincidence of these 2 events in a patient is rare, and this paper aimed to report such case. Patient concerns: A 40-year-old man presented with polyuria and polydipsia for 5 years. The symptoms had been relieved well by drug therapy for >4 years, until the drugs could not control the symptoms anymore and an extensively enlarged thyroid gland was noticed. Diagnoses: Thyroid ultrasound showed a nodule with microcalcification in the upper right lobe, positron emission tomography/computer tomography scan demonstrated thyroid hypermetabolism, and fine needle aspiration (FNA) revealed PTC. Right lobectomy of the thyroid and cervical lymph node biopsy verified the diagnosis “LCH of the thyroid complicated by PTC.” Interventions: The ultrasound-guided FNA biopsy was performed prior to right lobectomy of the thyroid and cervical lymph node biopsy. Postoperative histopathological examination confirmed the diagnosis, after which the patient received adjuvant chemotherapy. Outcomes: After 5 cycles of adjuvant chemotherapy, the patient had been followed up for 2 years. LCH was controlled satisfactorily and there was no significant sign of recurrence or metastasis of PTC. Lessons: LCH of the thyroid complicated by PTC is rare. Thyroid involvement should always be considered in the differential diagnosis of LCH patients. Surgery for PTC followed by chemotherapy for LCH may be the suitable treatment. |
| Databáze: | OpenAIRE |
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