Mussel-mimicking sulfobetaine-based copolymer with metal tunable gelation, self-healing and antibacterial capability
| Autor: | Peter Kasak, Jaroslav Mosnáček, Jassim Al-Khori, Mariam Al Ali Al-Maadeed, Ali Abdulrahman Ahmad, Mário Špírek, Miroslav Mrlik |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Gelation
Chemistry(all) General Chemical Engineering Self-healing Neurophysiology 02 engineering and technology 010402 general chemistry 01 natural sciences Redox Antibacterial properties Metal lcsh:Chemistry Polymer chemistry Copolymer Self-healing materials Viscoelastic properties MTT assay Chelation polysulfobetaine Amines Covalently cross-linked Human dermal fibroblasts Metal coordination Crosslinking Polysulfobetaines Chemistry Hydrogels Viscoelasticity General Chemistry Molluscs Fibroblasts 021001 nanoscience & nanotechnology catecholamine polymers 0104 chemical sciences Antibacterial lcsh:QD1-999 Covalent bond Metals visual_art Self-healing hydrogels visual_art.visual_art_medium Chemical Engineering(all) Oxidative coupling of methane Cell culture 0210 nano-technology |
| Zdroj: | Arabian Journal of Chemistry Arabian Journal of Chemistry, Vol 13, Iss 1, Pp 193-204 (2020) |
| Popis: | In the present study, the sulfobetaine-based copolymer bearing a dopamine functionality showed gel formation adjusted by the application of metal salts for gelation and various values of pH. Normally, the liquid-like solution of the sulfobetaine-based copolymer and metal cross-linkers is transformed to a gel-like state upon increasing the pH values in the presence of Fe3+ and Ti3+. Metal-induced coordination is reversible by means of the application of EDTA as a chelating agent. In the case of Ag+ ions, the gel is formed through a redox process accompanied with the oxidative coupling of the dopamine moieties and Ag0 particle formation. Mussel-mimicking and metal-dependent viscoelastic properties were observed for Fe3+, Ti3+, and Ag+ cross-linking agents, with additionally enhanced self-healing behavior in comparison with the covalently cross-linked IO4 − analogues. Antibacterial properties can be achieved both in solution and on the surface using the proper concentration of Ag+ ions used for gelation; thus, a tunable amount of the Ag0 particles are formed in the hydrogel. The cytotoxicity was elucidated by the both MTT assay on the NIH/3T3 fibroblast cell line and direct contact method using human dermal fibroblast cell (F121) and shows the non-toxic character of the synthesized copolymer. © 2017 The Authors Qatar University [QUUG-CAM-2017-1]; Ministry of Education, Youth and Sports of the Czech Republic - Program NPU I [LO1504]; Maersk Oil R&TC Qatar project; Qatar National Research Fund (Qatar Foundation) [9 - 219-2-105] |
| Databáze: | OpenAIRE |
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