Lack of MMTV Superantigen Presentation in MHC Class II-Deficient Mice
| Autor: | Ulrich Beutner, Eliyahu Kraus, Brigitte T. Huber, Brian McLellan |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Lymphoid Tissue
T cell Immunology CD1 Clonal Deletion Mice Inbred Strains chemical and pharmacologic phenomena Virus Replication Minor Lymphocyte Stimulatory Antigens Mice Peyer's Patches Mammary Glands Animal Proviruses T-Lymphocyte Subsets MHC class I medicine Animals Cytotoxic T cell Antigens Viral Tumor Mice Knockout Antigen Presentation MHC class II Hybridomas Superantigens biology Antigen processing Histocompatibility Antigens Class II MHC restriction Tumor Virus Infections Milk medicine.anatomical_structure Animals Newborn Mammary Tumor Virus Mouse DNA Viral biology.protein Female CD8 |
| Zdroj: | Cellular Immunology. 168:141-147 |
| ISSN: | 0008-8749 |
| DOI: | 10.1006/cimm.1996.0060 |
| Popis: | Mammary tumor viruses (MMTVs) as well as their endogenous counterparts encode superantigens which react with T cells expressing particular T cell receptor Vβ chains. Several lines of evidence indicated that MHC class II is required for the functional presentation of these superantigens. Here we provide direct proof that the function of superantigens is abrogated in the absence of MHC class II expression. No deletion of Mls-1-reactive T cells was observed in MHC class II-deficient mice, and splenocytes from these animals did not stimulate Mls-1-reactive T cell hybridsin vitro.Furthermore, the viral spread in MHC class II-deficient mice, maternally infected with MMTV(C3H), was severely reduced. While initial infection in the gut-associated lymphocytes was comparable between MHC class II-deficient and normal mice, the level of infection in the spleen and the mammary tissue was much lower in the deficient animals. Quantitation of proviral DNA in spleen revealed a direct correlation between the magnitude of superantigen stimulation and degree of infection. These experiments document the direct effect of superantigen stimulation on viral amplification. |
| Databáze: | OpenAIRE |
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