HIV antibodies for treatment of HIV infection
Autor: | Guido Ferrari, David M. Margolis, Richard A. Koup |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
medicine.drug_class HIV Antigens 030106 microbiology Immunology Human immunodeficiency virus (HIV) HIV Infections HIV Antibodies medicine.disease_cause Monoclonal antibody Virus Article 03 medical and health sciences Immune system Viral Envelope Proteins Antiretroviral Therapy Highly Active medicine Immunology and Allergy Animals Humans Immune Evasion Antibody-dependent cell-mediated cytotoxicity biology Effector Antibody-Dependent Cell Cytotoxicity Viral Load Virology Combined Modality Therapy Clinical trial Disease Models Animal 030104 developmental biology biology.protein HIV-1 Immunotherapy Antibody |
DOI: | 10.17615/pw9j-t232 |
Popis: | The bar is high to improve on current combination antiretroviral therapy (ART), now highly effective, safe, and simple. However, antibodies that bind the HIV envelope are able to uniquely target the virus as it seeks to enter new target cells, or as it is expressed from previously infected cells. Furthermore, the use of antibodies against HIV as a therapeutic may offer advantages. Antibodies can have long half-lives, and are being considered as partners for long-acting antiretrovirals for use in therapy or prevention of HIV infection. Early studies in animal models and in clinical trials suggest that such antibodies can have antiviral activity but, as with small-molecule antiretrovirals, the issues of viral escape and resistance will have to be addressed. Most promising, however, are the unique properties of anti-HIV antibodies: the potential ability to opsonize viral particles, to direct antibody-dependent cellular cytotoxicity (ADCC) against actively infected cells, and ultimately the ability to direct the clearance of HIV-infected cells by effector cells of the immune system. These distinctive activities suggest that HIV antibodies and their derivatives may play an important role in the next frontier of HIV therapeutics, the effort to develop treatments that could lead to an HIV cure. |
Databáze: | OpenAIRE |
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