Evaluation of the immature platelet fraction contribute to the differential diagnosis of hereditary, immune and other acquired thrombocytopenias
| Autor: | Joyce M. Annichino-Bizzacchi, Maria de Fatima Pereira Gilberti, Maiara Marx Luz Fiusa, E. de Paula, Marina Pereira Colella, Carolina Costa-Lima, Margareth C. Ozelo, Samuel de Souza Medina, Kleber Yotsumoto Fertrin, F. L. B. Ferreira, Loredana Nilkenes Gomes da Costa, Fernanda Andrade Orsi |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Blood Platelets Male Science Population Hereditary macrothrombocytopenia 030204 cardiovascular system & hematology Immature Platelet Article Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Immune system hemic and lymphatic diseases medicine Humans Platelet education Aged education.field_of_study Multidisciplinary Hematologic Tests business.industry Bone marrow failure Diagnostic algorithms Middle Aged medicine.disease Thrombocytopenia 030220 oncology & carcinogenesis Immunology Medicine Female Differential diagnosis business |
| Zdroj: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) |
| ISSN: | 2045-2322 |
| Popis: | The differential diagnosis of immune (ITP) and hereditary macrothrombocytopenia (HM) is key to patient management. The immature platelet fraction (IPF) represents the subset of circulating platelets with higher RNA content, and has been shown to distinguish hypo- from hyperproliferative thrombocytopenias. Here we evaluated the diagnostic accuracy of IPF in the differential diagnosis between HM and other thrombocytopenias in a population of patients with post-chemotherapy thrombocytopenia (n = 56), bone marrow failure (n = 22), ITP (n = 105) and HM (n = 27). TPO levels were also measured in HM and ITP matched for platelet counts. Platelet counts were similar in all patient groups. Higher IPF values were observed in both ITP (12.3%; 2.4–65.6%) and HM (29.8%; 4.6–65.9%) compared to hypoproliferative thrombocytopenias. IPF values were also higher in HM compared to ITP, yielding a diagnostic accuracy of 0.80 (95%CI 0.70–0.90; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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