Spaceflight Activates Lipotoxic Pathways in Mouse Liver
| Autor: | Moshe Levi, Jacob E. Friedman, Jeffrey L. Suhalim, Michael J. Pecaut, Virginia L. Ferguson, David J. Orlicky, Karen R. Jonscher, Ted A. Bateman, Eric O. Potma, Mary L. Bouxsein, Louis S. Stodieck, Alba Alfonso-Garcia, Daila S. Gridley |
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| Přispěvatelé: | Aspichueta, Patricia |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Physiology Liver cytology Messenger Gene Expression Organic chemistry lcsh:Medicine Astronomical Sciences Inbred C57BL Biochemistry Oral and gastrointestinal law.invention Mice law Lipid droplet Nonalcoholic fatty liver disease Medicine and Health Sciences Bile 2.1 Biological and endogenous factors Aetiology Vitamin A lcsh:Science Liver injury Multidisciplinary Liver Diseases Systems Biology Liver Disease Fatty Acids Fatty liver Vitamins Space Exploration Lipids Body Fluids Physical sciences Chemistry Liver Female Metabolic Pathways Anatomy Research Article medicine.medical_specialty General Science & Technology Chronic Liver Disease and Cirrhosis Gastroenterology and Hepatology Biology Spaceflight Chemical compounds 03 medical and health sciences Internal medicine Organic compounds Genetics medicine Hepatic Stellate Cells Animals Metabolomics PPAR alpha Nutrition 030102 biochemistry & molecular biology Gene Expression Profiling Prevention Body Weight lcsh:R Biology and Life Sciences Lipid Droplets Space Flight medicine.disease Hepatic stellate cell activation Fatty Liver Metabolism 030104 developmental biology Endocrinology Hepatic stellate cell RNA lcsh:Q Digestive Diseases Biomarkers |
| Zdroj: | PLoS ONE, Vol 11, Iss 4, p e0152877 (2016) PloS one, vol 11, iss 4 PLoS ONE |
| DOI: | 10.17615/gpdr-we90 |
| Popis: | Spaceflight affects numerous organ systems in the body, leading to metabolic dysfunction that may have long-term consequences. Microgravity-induced alterations in liver metabolism, particularly with respect to lipids, remain largely unexplored. Here we utilize a novel systems biology approach, combining metabolomics and transcriptomics with advanced Raman microscopy, to investigate altered hepatic lipid metabolism in mice following short duration spaceflight. Mice flown aboard Space Transportation System -135, the last Shuttle mission, lose weight but redistribute lipids, particularly to the liver. Intriguingly, spaceflight mice lose retinol from lipid droplets. Both mRNA and metabolite changes suggest the retinol loss is linked to activation of PPARα-mediated pathways and potentially to hepatic stellate cell activation, both of which may be coincident with increased bile acids and early signs of liver injury. Although the 13-day flight duration is too short for frank fibrosis to develop, the retinol loss plus changes in markers of extracellular matrix remodeling raise the concern that longer duration exposure to the space environment may result in progressive liver damage, increasing the risk for nonalcoholic fatty liver disease. |
| Databáze: | OpenAIRE |
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