Instantaneous preparation of radiolabeled 5-iodo-2′-deoxyuridine
| Autor: | S. James Adelstein, Ying Z. Zhang, Catherine F. Foulon, Amin I. Kassis |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
chemistry.chemical_classification
Radiation 5 iodo 2 deoxyuridine Chromatography Aqueous solution Chemistry Radiochemistry Iodide Reproducibility of Results Mercury High-performance liquid chromatography Deoxyuridine Iodine Radioisotopes chemistry.chemical_compound Idoxuridine Isotope Labeling Iodine-123 Chemical preparation Indicators and Reagents Chromatography High Pressure Liquid |
| Zdroj: | Applied Radiation and Isotopes. 46:1039-1046 |
| ISSN: | 0969-8043 |
| DOI: | 10.1016/0969-8043(95)00214-x |
| Popis: | The fastest and most reliable preparation of radiolabeled 5-iodo-2′-deoxyuridine ([ 123/125/131 I]IUdR) is accomplished by iododemetallation. We describe a series of improvements to a previously published synthesis of radiolabeled IUdR by demercuration whereby [ 123/125/131 I]IUdR is synthesized instantly following the incubation of an aqueous solution of the chloromercury precursor with Na 123/125/131 I in the presence of Iodogen. The total procedure is completed in 5 min and does not require purification. Mercury content is low and HPLC indicates the total transformation of iodide into IUdR with no detectable UV-absorbing by-products. |
| Databáze: | OpenAIRE |
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