Prevention of Carcinogenesis and Development of Gastric and Colon Cancers by 2-Aminophenoxazine-3-one (Phx-3): Direct and Indirect Anti-Cancer Activity of Phx-3
| Autor: | Keisuke Miyazawa, Takafumi Tabuchi, Akio Tomoda |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Oncology
medicine.medical_specialty Carcinogenesis Colorectal cancer 2-aminophenoxazine-3-one Antineoplastic Agents Review medicine.disease_cause Catalysis gastric and colon cancers lcsh:Chemistry Inorganic Chemistry neutrophils Stomach Neoplasms Internal medicine Oxazines medicine Animals Humans Phx-3 Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy biology business.industry digestive oral and skin physiology Organic Chemistry apoptosis Cancer General Medicine Helicobacter pylori medicine.disease biology.organism_classification Ulcerative colitis digestive system diseases In vitro Computer Science Applications lcsh:Biology (General) lcsh:QD1-999 Apoptosis Colonic Neoplasms business |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 14, Iss 9, Pp 17573-17583 (2013) |
| ISSN: | 1422-0067 |
| Popis: | 2-Aminophenoxazine-3-one (Phx-3), an oxidative phenoxazine, exerts strong anticancer effects on various cancer cell lines originating from different organs, in vitro. This article reviews new aspects for the prevention of carcinogenesis and development of gastric and colon cancers by Phx-3, based on the strong anticancer effects of Phx-3 on gastric and colon cancer cell lines (direct anticancer effects of Phx-3 for preventing development of cancer), the bacteriocidal effects of Phx-3 against Helicobacter pylori associated with carcinogenesis of gastric cancer (indirect anticancer effects for preventing carcinogenesis of gastric cancer), and the proapoptotic activity of Phx-3 against human neutrophils involved in the incidence of ulcerative colitis associated with a high colon cancer risk (indirect anticancer effects for preventing carcinogenesis of colon cancer). |
| Databáze: | OpenAIRE |
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