Staging of non-small cell lung cancer using integrated PET/CT
| Autor: | Seth Kligerman, Subba R. Digumarthy |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
PET-CT
Lung Neoplasms medicine.diagnostic_test business.industry General Medicine For Attenuation Correction Positron emission tomography Carcinoma Non-Small-Cell Lung medicine Transmission Scan Humans Radiology Nuclear Medicine and imaging Positron emission Tomography Nuclear medicine business Tomography X-Ray Computed Image resolution Correction for attenuation Neoplasm Staging Tomography Emission-Computed |
| Zdroj: | AJR. American journal of roentgenology. 193(5) |
| ISSN: | 1546-3141 |
| Popis: | 1203 glucose transporters on the cell membrane. The glucose is then converted to FDG-6phosphate, which cannot be further metabolized and remains trapped in the cell. Because of greater accumulation in cancer cells, more positron emission events occur in the tumor compared with surrounding normal tissue. As hundreds of thousands of coincidence events occur, they can be statistically traced back to their origin, allowing spatial localization. Due to the relatively poor spatial resolution of PET, disease localization often can prove difficult. To circumvent this problem, CT is combined with PET to provide spatially matched morphologic and functional data. PET and CT images can be integrated using three different techniques (Table 1). Although there are advantages and disadvantages to each technique, the integrated PET/CT study using a single machine provides the best coregistration of physiologic and anatomic detail [2]. In the integrated machine, both a diagnostic CT scan and a low-dose transmission scan are obtained. The diagnostic CT scan, often obtained with the administration of contrast material, provides excellent anatomic data. By creating an attenuation correction map, the transmission CT allows for a reduction in attenuation correction artifacts. These artifacts occur because of the greater attenuation of photons originating deeper within the body or within or adjacent to dense structures, such as bone, compared with those originating from the surface of the body or within or adjacent to less dense structures. The use of the transmission CT for attenuation correction also significantly reduces the PET scanning time by up to 40% compared with a standalone PET scanner [3]. Both the diagnostic CT and the transmission CT can be fused with the PET images. Although the anatomic detail is superior in the diagnostic CT scan, the transmission CT scan provides more precise Staging of Non–Small Cell Lung Cancer Using Integrated PET/CT |
| Databáze: | OpenAIRE |
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