Reduced corneal nerve fibre length in prediabetes and type 2 diabetes: The Maastricht Study
| Autor: | Alfredo Ruggeri, Pedro Guimarães, Ronald M.A. Henry, Rudy M.M.A. Nuijts, Carroll A.B. Webers, Miranda T. Schram, Nicolaas C. Schaper, Jan S. A. G. Schouten, Eline E B De Clerck, Coen D.A. Stehouwer, Tos T. J. M. Berendschot, Pieter C. Dagnelie, Renée S. Koolschijn |
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| Přispěvatelé: | Medical Image Analysis, MUMC+: MA UECM AIOS (9), RS: MHeNs - R3 - Neuroscience, Oogheelkunde, MUMC+: MA UECM Oogartsen MUMC (9), RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, MUMC+: *AB Refractie Chirurgie Oogheelkunde (9), MUMC+: HVC Pieken Maastricht Studie (9), RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, Interne Geneeskunde, MUMC+: MA Endocrinologie (9), RS: CAPHRI - R2 - Creating Value-Based Health Care, RS: CAPHRI - R5 - Optimising Patient Care, Epidemiologie, MUMC+: MA Interne Geneeskunde (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Maag Darm Lever (9), MUMC+: MA Hematologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Reumatologie (9), MUMC+: *MA Oogheelkunde (3) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Corneal nerve corneal nerves RETINOPATHY Type 2 diabetes prediabetes Carbohydrate metabolism SDG 3 – Goede gezondheid en welzijn 03 medical and health sciences 0302 clinical medicine Corneal erosion SDG 3 - Good Health and Well-being OPHTHALMIC MARKERS Cornea Ophthalmology Diabetes mellitus medicine CONFOCAL MICROSCOPY Prediabetes INNERVATION COMPLICATIONS business.industry NEUROPATHY Nerve plexus General Medicine Original Articles medicine.disease eye diseases Surgery medicine.anatomical_structure DENSITY 030221 ophthalmology & optometry corneal confocal microscopy Original Article GLUCOSE-TOLERANCE sense organs type 2 diabetes SENSITIVITY PLEXUS business 030217 neurology & neurosurgery |
| Zdroj: | Acta Ophthalmologica Acta Ophthalmologica, 98(5), 485-491. Wiley-Blackwell Acta Ophthalmologica, 98(5), 485-491. Wiley |
| ISSN: | 1755-3768 1755-375X |
| Popis: | Purpose: In individuals with diabetes, injury to the corneal nerve fibres predisposes to delayed corneal epithelial healing, reduced corneal sensitivity and corneal erosion. We investigated to what extent a reduction in corneal nerve fibre length (CNFL) is present in individuals with prediabetes or type 2 diabetes (DM2) compared with individuals with normal glucose metabolism (NGM). Methods: Using composite images acquired by corneal confocal microscopy, we assessed total CNFL per mm2 in the subbasal nerve plexus of the cornea in 134 participants (mean age 59 ± 8 years, 49% men, 87 NGM, 20 prediabetes, 27 DM2). Multivariable linear regression was used to assess the association between CNFL and glucose metabolism status, adjusted for age and sex. Results: In individuals with type 2 diabetes, the mean CNFL was significantly reduced [β = −1.86 mm/mm2 (95% CI −3.64 to −0.08), p = 0.04], as compared with individuals with normal glucose metabolism after adjustment for age and sex. Part of the reduction was present in individuals with prediabetes [β = −0.96 mm/mm2 (95% CI −2.91 to 0.99), p = 0.34], with a linear trend of corneal nerve fibre reduction with severity of glucose metabolism status (p trend = 0.04). Conclusions: A significant reduction in CNFL was found in individuals with DM2 compared with individuals with NGM. A trend of reduction in CNFL was observed between individuals with NGM and prediabetes. The reduction in corneal nerve fibre length could contribute to a delayed corneal healing and an increased risk for corneal complications after surgery. |
| Databáze: | OpenAIRE |
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