Assessment of antioxidant, antitumor and pro-apoptotic effects of Salvia fruticosa Mill. subsp. thomasii (Lacaita) Brullo, Guglielmo, PavoneTerrasi (Lamiaceae)
| Autor: | Nicodemo G. Passalacqua, Jessica Ceramella, Monica Rosa Loizzo, Mariarosaria Leporini, Marco Bonesi, Maria Stefania Sinicropi, Federica Menichini, Rosa Tundis, Domenico Iacopetta |
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| Rok vydání: | 2017 |
| Předmět: |
Antioxidant
DPPH medicine.medical_treatment Apoptosis Toxicology medicine.disease_cause 01 natural sciences Antioxidants Lipid peroxidation Rutin chemistry.chemical_compound Salvia fruticosa Cell Line Tumor medicine Humans Salvia biology Traditional medicine 010405 organic chemistry Plant Extracts General Medicine Plant Components Aerial biology.organism_classification Antineoplastic Agents Phytogenic 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Biochemistry Lamiaceae Luteolin Oxidative stress Food Science |
| Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 106 |
| ISSN: | 1873-6351 |
| Popis: | The aim of the present study was to investigate the in vitro antioxidant and antitumor effects of Salvia fruticosa Mill subsp. thomasii (Lacaita) Brullo, Guglielmo, Pavone & Terrasi (Lamiaceae). The aerial parts were extracted by maceration with methanol. This extract was partitioned with methanol and n-hexane. Luteolin, luteolin 7-O-glucoside, rutin and salvigenin were isolated from the methanol-soluble fraction. n-Hexane fraction showed viridiflorol, β-pinene, 1,8-cineole, as main components. The methanol-soluble fraction exerted antitumor activity against human breast cancer (MCF-7 and MDA-MB-231) and human colorectal carcinoma (RKO and Caco-2) cells. TUNEL test revealed that S. fruticosa subsp. thomasii leads to cells death by apoptosis, with low cytotoxic effects on non-tumoral 3T3-L1 cells. Moreover, it exerted the highest protection of lipid peroxidation and reduced the oxidative stress induced by menadione treatment in 3T3-L1 murine fibroblasts. S. fruticosa subsp. thomasii bioactivity could promote its use not only as food but also in nutraceutical/pharmaceutical industries. |
| Databáze: | OpenAIRE |
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