Altered structure and reduced distensibility of arteries in Dahl salt-sensitive rats
| Autor: | Geza Simon, Marta Jaeckel |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Physiology Systolic hypertension Sodium Lumen (anatomy) chemistry.chemical_element Vasodilation Calcium Iliac Artery Internal medicine Internal Medicine medicine Animals Iliac artery Rats Inbred Dahl Dose-Response Relationship Drug business.industry Sodium Dietary Arteries Anatomy medicine.disease Rats Carotid Arteries Blood pressure medicine.anatomical_structure chemistry Cardiology Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | Journal of Hypertension. 21:311-319 |
| ISSN: | 0263-6352 |
| DOI: | 10.1097/00004872-200302000-00022 |
| Popis: | Objectives The role of salt sensitivity in arterial stiffening and the structural basis of reduced arterial distensibility were investigated in Dahl salt-sensitive (DS) rats. Methods Three-month-old male DS rats received a norma (0.7% NaCI) or a high-sodium (2% NaCI) diet for 3 months. Dahl salt-resistant (DR) rats were controls. Pressure-volume (distensibility) relationships were measured in invitro-perfused segments of right carotid and iliac arteries, in the presence and absence of extracellular calcium. The left carotid and iliac arteries were perfusion-fixed in situ at 100 mmHg for morphometric measurements. Results The average monthly tail systolic blood pressure (SBP) of DS rats on normal and high-sodium diets were increased compared to that of DR rats. Compared to controls, carotid and iliac artery pressure-volume curves of DS rats on normal and high-sodium diets were shifted toward the pressure axis, without a change in elastic moduli. In DS rats, reduced distensibility of the carotid artery was accompanied by increased lumen diameter and increased thickness of media and elastic lamellae, the wall to lumen ratio being unchanged; wall thickness was increased and lumen diameter unchanged in the iliac artery. The high-sodium diet had no effect on either distensibility or dimensions of carotid and iliac arteries in DS or DR rats. Conclusion Geometry (increased or unchanged lumen and increased wall thickness), rather than increased stiffness of wall components, appears to be the cause of reduced distensibility of arteries in DS rats. Structural and functional adaptation to salt sensitivity may occur on what is considered a 'normal' sodium diet |
| Databáze: | OpenAIRE |
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