Cefdinir (FK482), an orally administered cephalosporin in vitro activity comparison against recent clinical isolates from five medical centers and determination of MIC quality control guidelines
| Autor: | Patrick R. Murray, Ronald N. Jones, E.Hugh Gerlach, John A. Washington, Stephen D. Allen, Franklin P. Koontz, Michael A. Pfaller, Meridith E. Erwin |
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| Rok vydání: | 1992 |
| Předmět: |
Microbiology (medical)
medicine.drug_class Cephalosporin Drug Evaluation Preclinical Cefotaxime Microbial Sensitivity Tests Microbiology Enterobacteriaceae Cefixime polycyclic compounds medicine Humans Cefaclor Cefdinir Cefuroxime Gram-Negative Aerobic Bacteria biology business.industry Cefadroxil General Medicine biochemical phenomena metabolism and nutrition biology.organism_classification Anti-Bacterial Agents Cephalosporins Gram-Positive Cocci Infectious Diseases bacteria business Morganella morganii Enterobacter cloacae medicine.drug |
| Zdroj: | Diagnostic Microbiology and Infectious Disease. 15:537-543 |
| ISSN: | 0732-8893 |
| DOI: | 10.1016/0732-8893(92)90105-3 |
| Popis: | Cefdinir, a new oral cephalosporin, was compared to cefaclor, cefadroxil, cefixime, and cefuroxime against greater than 5000 recent aerobic clinical isolates. This multicenter study revealed broad-spectrum cefdinir activity against all Enterobacteriaceae (MIC50s, 0.06-2 micrograms/ml) except Enterobacter cloacae, Morganella morganii, Proteus vulgaris, and Serratia marcescens (MIC50s, greater than or equal to 4 micrograms/ml). Oxacillin-susceptible staphylococci (MIC90s, 0.5-2 micrograms/ml), beta-hemolytic Streptococcus group B (MIC90, 0.06 micrograms/ml), and Acinetobacter lwoffii were also susceptible to cefdinir. The activity of cefdinir was similar to that of cefixime and cefuroxime against Gram-negative organisms and superior to all tested oral cephems when tested against Gram-positive cocci. None of the cephalosporins were active against oxacillin-resistant Staphylococcus spp., enterococci, Pseudomonas spp., or Xanthomonas maltophilia. MIC quality control range guidelines were established for the strains recommended by the National Committee for Clinical Laboratory Standards documents. |
| Databáze: | OpenAIRE |
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