| Autor: |
Clarisa M. Buckner, Lela Kardava, Omar El Merhebi, Sandeep R. Narpala, Leonid Serebryannyy, Bob C. Lin, Wei Wang, Xiaozhen Zhang, Felipe Lopes de Assis, Sophie E.M. Kelly, I-Ting Teng, Genevieve E. McCormack, Lauren H. Praiss, Catherine A. Seamon, M. Ali Rai, Heather Kalish, Peter D. Kwong, Michael A. Proschan, Adrian B. McDermott, Anthony S. Fauci, Tae-Wook Chun, Susan Moir |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Cell. 185:4333-4346.e14 |
| ISSN: |
0092-8674 |
| DOI: |
10.1016/j.cell.2022.09.032 |
| Popis: |
SARS-CoV-2 mRNA booster vaccines provide protection from severe disease, eliciting strong immunity that is further boosted by previous infection. However, it is unclear whether these immune responses are affected by the interval between infection and vaccination. Over a 2-month period, we evaluated antibody and B cell responses to a third-dose mRNA vaccine in 66 individuals with different infection histories. Uninfected and post-boost but not previously infected individuals mounted robust ancestral and variant spike-binding and neutralizing antibodies and memory B cells. Spike-specific B cell responses from recent infection (180 days) were elevated at pre-boost but comparatively less so at 60 days post-boost compared with uninfected individuals, and these differences were linked to baseline frequencies of CD27 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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