Dissimilarity in Sulcal Width Patterns in the Cortex can be Used to Identify Patients with Schizophrenia with Extreme Deficits in Cognitive Performance
| Autor: | Anouck Schippers, René S. Kahn, Hilleke E. Hulshoff Pol, Neeltje E.M. van Haren, Pedro M. Gordaliza, Javier Santonja, Celso Arango, Joost Janssen, Clara Alloza, Hugo G. Schnack, Elizabeth E.L. Buimer, Lucía de Hoyos, Covadonga M. Díaz-Caneja, Wiepke Cahn |
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| Přispěvatelé: | Child and Adolescent Psychiatry / Psychology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Audiology Severity of Illness Index 03 medical and health sciences Young Adult 0302 clinical medicine Similarity (network science) SDG 3 - Good Health and Well-being Cortex (anatomy) medicine Humans In patient Cognitive Dysfunction Effects of sleep deprivation on cognitive performance Longitudinal Studies 030304 developmental biology Aged Cerebral Cortex 0303 health sciences medicine.diagnostic_test business.industry Brain morphometry Healthy subjects Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Schizophrenia Homogeneous Female business 030217 neurology & neurosurgery Regular Articles |
| Zdroj: | Schizophr Bull Schizophrenia Bulletin, 47(2), 552-561. Oxford University Press Schizophrenia Bulletin |
| ISSN: | 1745-1701 0586-7614 |
| DOI: | 10.1093/schbul/sbaa131 |
| Popis: | Schizophrenia is a biologically complex disorder with multiple regional deficits in cortical brain morphology. In addition, interindividual heterogeneity of cortical morphological metrics is larger in patients with schizophrenia when compared to healthy controls. Exploiting interindividual differences in the severity of cortical morphological deficits in patients instead of focusing on group averages may aid in detecting biologically informed homogeneous subgroups. The person-based similarity index (PBSI) of brain morphology indexes an individual’s morphometric similarity across numerous cortical regions amongst a sample of healthy subjects. We extended the PBSI such that it indexes the morphometric similarity of an independent individual (eg, a patient) with respect to healthy control subjects. By employing a normative modeling approach on longitudinal data, we determined an individual’s degree of morphometric dissimilarity to the norm. We calculated the PBSI for sulcal width (PBSI-SW) in patients with schizophrenia and healthy control subjects (164 patients and 164 healthy controls; 656 magnetic resonance imaging scans) and associated it with cognitive performance and cortical sulcation index. A subgroup of patients with markedly deviant PBSI-SW showed extreme deficits in cognitive performance and cortical sulcation. Progressive reduction of PBSI-SW in the schizophrenia group relative to healthy controls was driven by these deviating individuals. By explicitly leveraging interindividual differences in the severity of PBSI-SW deficits, neuroimaging-driven subgrouping of patients is feasible. As such, our results pave the way for future applications of morphometric similarity indices for subtyping of clinical populations. |
| Databáze: | OpenAIRE |
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