Anosmia is associated with lower in-hospital mortality in COVID-19

Autor: Alba Chavarría-Miranda, Gonzalo Valle-Peñacoba, Mercedes de Lera, Isabel Hernández-Pérez, Juan F. Arenillas, María Gutiérrez-Sánchez, David García-Azorín, Álvaro Sierra, Cristina López-Sanz, Elena Martínez-Velasco, Ángel L Guerrero, Beatriz Gómez-Vicente, Javier Trigo, María Pedraza, Blanca Talavera, Paula Simón-Campo, Enrique Martínez-Pías
Jazyk: angličtina
Rok vydání: 2020
Předmět:
myalgia
Male
Multivariate analysis
emergency department
(ED)
Clinical presentation
chronic obstructive pulmonary disease
(COPD)
Comorbidity
odds ratio
(OR)
law.invention
0302 clinical medicine
COVID-19 Testing
law
lactate dehydrogenase
(LDH)
procalcitonin
(PCT)
Medicine
030212 general & internal medicine
Hospital Mortality
reference value
(RV)
Computerized Tomography
(CT)
Mortality rate
Middle Aged
Prognosis
Intensive care unit
Hospitalization
creatine-kinase
(CK)
Intensive Care Units
Coronavirus disease 2019
(Covid-19)
Neurology
real-time reverse-transcriptase-polymerase-chain-reaction
(RT-PCR)
Regression Analysis
confidence intervals
(CI)
Female
chronic neurological disorders
(CND)
hemoglobin
(Hb)
medicine.symptom
medicine.medical_specialty
international normalized ratio
(INR)
Anosmia
Clinical Neurology
Article
03 medical and health sciences
Diabetes mellitus
Internal medicine
interleukine-6
(IL-6)
Humans
C-reactive protein
(CRP)
Mortality
strengthening the reporting in observational studies in epidemiology
(STROBE)
glomerular filtration rate corrected by body area
(GFR)
Aged
Retrospective Studies
standard of care
(SOC)
business.industry
COVID-19
Retrospective cohort study
medicine.disease
intensive care unit
(ICU)
interquartile range
(IQR)
COVID-19 Drug Treatment
modified Rankin scale
(mRS)
standard deviation
(SD)
Neurology (clinical)
business
030217 neurology & neurosurgery
Zdroj: Journal of the Neurological Sciences
Digital.CSIC. Repositorio Institucional del CSIC
instname
Popis: [Background] Anosmia is common in Coronavirus disease 2019, but its impact on prognosis is unknown. We analysed whether anosmia predicts in-hospital mortality; and if patients with anosmia have a different clinical presentation, inflammatory response, or disease severity.
[Methods] Retrospective cohort study including all consecutive hospitalized patients with confirmed Covid-19 from March 8th to April 11th, 2020. We determined all-cause mortality and need of intensive care unit (ICU) admission. We registered the first and worst laboratory parameters. Statistical analysis was done by multivariate logistic and linear regression.
[Results] We included 576 patients, 43.3% female, and aged 67.2 years in mean. Anosmia was present in 146 (25.3%) patients. Patients with anosmia were more frequently females, younger and less disabled and had less frequently hypertension, diabetes, smoking habit, cardiac and neurological comorbidities. Anosmia was independently associated with lower mortality (OR: 0.180, 95% CI: 0.069–0.472) and ICU admission (OR: 0.438, 95% CI: 0.229–0.838, p = 0.013). In the multivariate analysis, patients with anosmia had a higher frequency of cough (OR: 1.96, 95%CI: 1.18–3.28), headache (OR: 2.58, 95% CI: 1.66–4.03), and myalgia (OR: 1.74, 95% CI: 1.12–2.71). They had higher adjusted values of hemoglobin (+0.87, 95% CI: 0.40–1.34), lymphocytes (+849.24, 95% CI: 157.45–1541.04), glomerular filtration rate (+6.42, 95% CI: 2.14–10.71), and lower D-dimer (−4886.52, 95% CI: −8655.29-(−1117.75)), and C-reactive protein (−24.92, 95% CI: −47.35-(−2.48)).
[Conclusions] Hospitalized Covid-19 patients with anosmia had a lower adjusted mortality rate and less severe course of the disease. This could be related to a distinct clinical presentation and a different inflammatory response.
Databáze: OpenAIRE
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