Integrated analysis of microRNA regulation and its interaction with mechanisms of epigenetic regulation in the etiology of systemic lupus erythematosus

Autor: Lisandro Pacheco Lugo, Lorena Gomez Escorcia, Pablo Navarro Rodriguez, Hernan Lorenzi, Gustavo Aroca Martínez, Cecilia Fernández-Ponce, Joe Luis Villa, Henry J. González Torres, Maria del Carmen Marmolejo, Elkin Navarro Quiroz, Eduardo Sanchez, Kelvin Fernando Navarro, José Villarreal Camacho, Roberto Navarro Quiroz, Augusto Torres, Andres Cadena Bonfanti
Přispěvatelé: Bioquímica y Biología Molecular, Microbiología, Medicina Preventiva, Salud Pública
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
ADN
Biochemistry
Epigenesis
Genetic
White Blood Cells
0302 clinical medicine
Animal Cells
Databases
Genetic
Medicine and Health Sciences
Lupus Erythematosus
Systemic
Gene Regulatory Networks
Post-Translational Modification
Regulation of gene expression
Multidisciplinary
DNA methylation
T Cells
Chromatin
Nucleic acids
Histone
embryonic structures
Medicine
Epigenetics
Post-translational modification
Cellular Types
DNA modification
Chromatin modification
Research Article
Chromosome biology
Cell biology
In silico
Immune Cells
Science
Immunology
Computational biology
Biology
Systemic Lupus Erythematosus
Autoimmune Diseases
03 medical and health sciences
Systemic lupus erythematosus
Rheumatology
microRNA
DNA-binding proteins
Genetics
Transcription factors
Humans
Non-coding RNA
Gene
Transcription factor
Genetic Association Studies
Natural antisense transcripts
Blood Cells
Lupus erythematosus
Biology and life sciences
Lupus Erythematosus
Proteins
DNA
Regulatory Proteins
Gene regulation
body regions
MicroRNAs
030104 developmental biology
Gene Ontology
Lupus eritematós
biology.protein
RNA
Clinical Immunology
Gene expression
Clinical Medicine
Protein Processing
Post-Translational
030217 neurology & neurosurgery
Transcription Factors
Zdroj: PLoS ONE, Vol 14, Iss 6, p e0218116 (2019)
PLoS ONE 14(6): e0218116
RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
instname
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE
Repositorio Digital USB
Universidad Simón Bolívar
instacron:Universidad Simón Bolívar
ISSN: 1932-6203
Popis: The aim of this study was to identity in silico the relationships among microRNAs (miRNAs) and genes encoding transcription factors, ubiquitylation, DNA methylation, and histone modifications in systemic lupus erythematosus (SLE). To identify miRNA dysregulation in SLE, we used miR2Disease and PhenomiR for information about miRNAs exhibiting differential regulation in disease and other biological processes, and HMDD for information about experimentally supported human miRNA–disease association data from genetics, epigenetics, circulating miRNAs, and miRNA–target interactions. This information was incorporated into the miRNA analysis. High-throughput sequencing revealed circulating miRNAs associated with kidney damage in patients with SLE. As the main finding of our in silico analysis of miRNAs differentially expressed in SLE and their interactions with disease-susceptibility genes, post-translational modifications, and transcription factors; we highlight 226 miRNAs associated with genes and processes. Moreover, we highlight that alterations of miRNAs such as hsa-miR-30a-5p, hsa-miR-16-5p, hsa-miR-142-5p, and hsa-miR-324-3p are most commonly associated with post-translational modifications. In addition, altered miRNAs that are most frequently associated with susceptibility-related genes are hsa-miR-16-5p, hsamiR- 374a-5p, hsa-miR-34a-5p, hsa-miR-31-5p, and hsa-miR-1-3p.
Databáze: OpenAIRE
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