In vitro motility changes in Roux limb after Roux-en-Y reconstruction
| Autor: | Aydin C, S. Yildirim, Topcu O, A. Koyuncu, Dogan N, Gokakin Ak, Ihsan Bagcivan |
|---|---|
| Přispěvatelé: | [Gokakin, A. K.] Cumhuriyet Univ, Sch Med, Dept Gen Surg, TR-58140 Sivas, Turkey -- [Dogan, N. -- Gokakin, A. K. -- Koyuncu, A. -- Aydin, C. -- Topcu, O.] Cumhuriyet Univ, Fac Med, Dept Gen Surg, TR-58140 Sivas, Turkey -- [Bagcivan, I -- Yildirim, S.] Cumhuriyet Univ, Fac Med, Dept Pharmacol, TR-58140 Sivas, Turkey |
| Rok vydání: | 2014 |
| Předmět: |
Male
Roux stasis syndrome Economics and Econometrics Contraction (grammar) Gastroparesis medicine.medical_treatment Cholinergic Agonists Vagotomy Roux-en-Y Jejunum Tissue Culture Techniques Gastrectomy Muscarinic acetylcholine receptor Materials Chemistry Media Technology medicine Animals jejunum Rats Wistar business.industry nutritional and metabolic diseases Forestry Anastomosis Roux-en-Y Muscle Smooth electrical field stimulation Roux-en-Y anastomosis acetylcholine Acetylcholine Electric Stimulation Rats surgical procedures operative medicine.anatomical_structure motility Anesthesia Cholinergic business Free nerve ending medicine.drug |
| Zdroj: | Bratislavske lekarske listy. 115(6) |
| ISSN: | 0006-9248 |
| Popis: | WOS: 000339087300004 PubMed ID: 25023423 Background: The aim of this study is to compare the motility of Roux limb with that of normal segment. Materials and methods: Rats were divided into 3 equal groups as control, Roux-en-Y (Group A) and Roux-en-Y with vagotomy (Group B). Only midline incision and manipulations were applied in control group. Following distal gastrectomy, Roux-en-Y reconstruction was applied in Group A, while vagotomy Roux-en-Y gastrojejunostonny was applied in Group B. Rats were sacrificed 1 month later by cervical dislocations under anesthesia. The obtained jejunal segments were cut into four equal parts. The bath was 37 degrees C warm while 95 % 02 and 5 % CO2 gases were supplied in 10 ml bicarbonate Krebs' solution. Results: KCl responses were similar in all three groups. Acetylcholine contraction responses in the vagotomy and non-vagotomy Roux-en-Y groups was higher than in those in control group significantly (p < 0.05). This response in vagotomy Roux-en-Y group was also higher than that in non-vagotomy group (p < 0.05). The induced electrical field stimulation contraction response in the vagotomy + Roux-en-Y group was lower than those in control group and non-vagotomy group (p < 0.05). Conclusions: These results show that muscarinic receptor density and/or function may increase after vagotomy and non-vagotomy group operation, and vagotomy may contribute to this increase. The decrease in electrical signal response in vagotomy Roux-en-Y group may depend on the decrease in acetylcholine oscillation from the cholinergic nerve ending (Tab. 1, Fig. 5, Ref. 25). Text in PDF www.elis.sk. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|