Correlation of peripheral-blood gene expression with the extent of coronary artery stenosis
| Autor: | Eberhard Grube, Whittemore G. Tingley, Michael Elashoff, L. Kristin Newby, Geoffrey S. Ginsburg, William E. Kraus, Susan E. Daniels, Lutz Buellesfeld, Steven Rosenberg, James A. Wingrove, Amy J. Sehnert |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Coronary artery disease Cohort Studies Internal medicine Germany Genetics medicine North Carolina Humans Genetics (clinical) Aged Demography Regulation of gene expression Aged 80 and over medicine.diagnostic_test Microarray analysis techniques business.industry Reverse Transcriptase Polymerase Chain Reaction Case-control study Coronary Stenosis Reproducibility of Results Middle Aged medicine.disease Stenosis Gene Expression Regulation Case-Control Studies Cohort Angiography Cardiology Female Cardiology and Cardiovascular Medicine business Cohort study |
| Zdroj: | Circulation. Cardiovascular genetics. 1(1) |
| ISSN: | 1942-3268 |
| Popis: | Background— The molecular pathophysiology of coronary artery disease (CAD) includes cytokine release and a localized inflammatory response within the vessel wall. The extent to which CAD and its severity is reflected by gene expression in circulating cells is unknown. Methods and Results— From an initial coronary catheterization cohort we identified 41 patients, comprising 27 cases with angiographically significant CAD and 14 controls without coronary stenosis. Whole-genome microarray analysis performed on peripheral-blood mononuclear cells yielded 526 genes with >1.3-fold differential expression ( P P P Conclusions— Gene expression in peripheral-blood cells reflects the presence and extent of CAD in patients undergoing angiography. |
| Databáze: | OpenAIRE |
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