Antimicrobial 3-methylene flavanones

Autor:	Robert T. Buckler, David M. Lawler, David L. Garling, Frederick E. Ward, Dennis P. Cummings
Rok vydání:	1981
Předmět:	Flavonoids Bromine Bacteria Chemical Phenomena Chemistry chemistry.chemical_element Ring (chemistry) Antimicrobial Anti-Bacterial Agents chemistry.chemical_compound Drug Discovery Chlorine medicine Molecular Medicine Potency Organic chemistry Flavanone Hexachlorophene medicine.drug
Zdroj:	Journal of Medicinal Chemistry. 24:1073-1077
ISSN:	1520-4804 0022-2623
DOI:	10.1021/jm00141a011
Popis:	The antimicrobial activity previously attributed to flavanone Mannich bases was found to be due to their breakdown products, 3-methyleneflavanones. Among the latter compounds, highest potency was observed when the flavanone phenyl ring contained bromine or chlorine substituents. 3-Methylene-2-phenylflavanone (8) was synthesized and shown to be equal to hexachlorophene in tests against representative Gram-positive microorganisms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3442ab0bf8d20b2533731ac4a43678 https://doi.org/10.1021/jm00141a011 Zobrazit plný text záznamu