Ubiquitin proteasome system research in gastrointestinal cancer
| Autor: | Jia-Ling Zhong, Chang-Zhi Huang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Cellular process business.industry Gastroenterology Review Bioinformatics medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology Proteasome 030220 oncology & carcinogenesis Medicine Gastrointestinal cancer business Homeostasis |
| Zdroj: | World journal of gastrointestinal oncology. 8(2) |
| ISSN: | 1948-5204 |
| Popis: | The ubiquitin proteasome system (UPS) is important for the degradation of proteins in eukaryotic cells. It is involved in nearly every cellular process and plays an important role in maintaining body homeostasis. An increasing body of evidence has linked alterations in the UPS to gastrointestinal malignancies, including esophageal, gastric and colorectal cancers. Here, we summarize the current literature detailing the involvement of the UPS in gastrointestinal cancer, highlighting its role in tumor occurrence and development, providing information for therapeutic targets research and anti-gastrointestinal tumor drug design. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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