Preparation and in vitro and in vivo evaluation of quinolones with selective activity against gram-positive organisms
| Autor: | Dwight J. Hardy, Daniel T. W. Chu, Robert N. Swanson, Curt S. Cooper, Pamela L. Klock, Jacob J. Plattner |
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| Rok vydání: | 1992 |
| Předmět: |
4-Quinolones
Biological activity Microbial Sensitivity Tests Oxime medicine.disease_cause Gram-Positive Bacteria Pyrrolidine In vitro chemistry.chemical_compound Mice Structure-Activity Relationship Biochemistry chemistry Anti-Infective Agents In vivo Staphylococcus aureus Drug Discovery medicine Molecular Medicine Animals Female Piperidine Escherichia coli Infections Antibacterial agent |
| Zdroj: | Journal of medicinal chemistry. 35(8) |
| ISSN: | 0022-2623 |
| Popis: | A series of quinolones were prepared which contained oximes or substituted oximes as replacements for the amine substituents normally found on the pyrrolidine or piperidine fragments of quinolone antibacterial agents. These substituents led to compounds that had selective activity against Gram-positive organisms. These compounds showed in vivo activity against Staphylococcus aureus. Only compound 29 had in vivo activity against Streptococcus pneumoniae. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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