Development of a sustained fluoride delivery system
| Autor: | Gary E. Wnek, Eser Tufekci, Ozge Guney-Altay, Steven J. Lindauer, Shadeed M. Khan, Olga A. Baturina |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Dentistry
Orthodontics Dental Caries Elastomer Ion selective electrode Fluorides chemistry.chemical_compound Drug Delivery Systems Coated Materials Biocompatible Orthodontic Appliances Sodium fluoride Orthodontic Appliance Design business.industry Original Articles Polyethylene Controlled release Cariostatic Agents Demineralization Elastomers chemistry Sodium Fluoride Polyvinyls Delivery system Polyethylenes business Fluoride Nuclear chemistry |
| Zdroj: | Angle Orthod |
| ISSN: | 1945-7103 0003-3219 |
| DOI: | 10.2319/112309-664.1 |
| Popis: | OBJECTIVE: To develop a novel delivery system by which fluoride incorporated into elastomeric rings, such as those used to ligate orthodontic wires, will be released in a controlled and constant manner. MATERIALS AND METHODS: Polyethylene co-vinyl acetate (PEVA) was used as the model elastomer. Samples (N = 3) were prepared by incorporating 0.02 to 0.4 g of sodium fluoride (NaF) into previously prepared PEVA solution. Another group of samples prepared in the same manner were additionally dip-coated in PEVA to create an overcoat. Fluoride release studies were conducted in vitro using an ion selective electrode over a period of 45 days. The amount of fluoride released was compared to the optimal therapeutic dose of 0.7 µg F(−)/ring/d. RESULTS: Only coated samples with the highest fluoride content (group D, 0.4 g of NaF) were able to release fluoride at therapeutic levels. When fluoride release from coated and uncoated samples with the same amount of NaF were compared, it was shown that the dip-coating technique resulted in a fluoride release in a controlled manner while eliminating the initial burst effect. CONCLUSIONS: This novel fluoride delivery matrix provided fluoride release at a therapeutically effective rate and profile. |
| Databáze: | OpenAIRE |
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