Non-clinical toxicity of β -caryophyllene, a dietary cannabinoid: Absence of adverse effects in female Swiss mice
| Autor: | Chistiane Mendes Feitosa, George Laylson da Silva Oliveira, Ana Paula dos Santos C. L da Silva, Kátia da Conceição Machado, Fernanda R.C. Almeida, Keylla da Conceição Machado |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty food.ingredient medicine.medical_treatment Physiology Toxicology medicine.disease_cause Eating Mice 03 medical and health sciences 0302 clinical medicine food Toxicity Tests Acute medicine Animals Adverse effect Polycyclic Sesquiterpenes Dose-Response Relationship Drug Cannabinoids Plant Extracts business.industry Food additive Body Weight General Medicine Acute toxicity Diet Oxidative Stress 030104 developmental biology Toxicity Female Food Additives Histopathology Cannabinoid β caryophyllene business Sesquiterpenes 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Regulatory Toxicology and Pharmacology. 92:338-346 |
| ISSN: | 0273-2300 |
| DOI: | 10.1016/j.yrtph.2017.12.013 |
| Popis: | β-caryophyllene is a food additive that is found in food plants and has broad pharmacological potential. However, little toxicological information has been reported and its use is based on the fact that this bicyclic sesquiterpene is daily consumed as a plant food in much larger quantities than as a food additive. Thus, this study evaluated acute (14-day) and repeated-dose (28 days) oral β-caryophyllene toxicity in female Swiss mice analyzing changes in body weight, food intake, water intake, hematological and biochemical parameters, organ weight after necropsy, oxidative stress markers and histopathology of various tissues. Acute (300 and 2000 mg/kg) and repeated-dose (300 and 2000 mg/kg) toxicity studies were performed according to the Organization for Economic Cooperation and Development (OECD) guideline 423 and 407, respectively. There was absence of adverse clinical signs and mortality in any animal subjected to acute and repeated-dose toxicity study. In addition, no significant changes in body weight, food and water intake, oxidative stress biomarkers, hematological and biochemical parameters were observed when compared to control group from single-dose and repeated-dose toxicity study. Therefore, the results of this study provide an understanding of the toxicity profile of β-caryophyllene which can be considered a compound with toxicity at doses higher than 2000 mg/kg body weight. |
| Databáze: | OpenAIRE |
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