The relationship between plasma renin activity and serum lipid profiles in patients with primary arterial hypertension
Autor: | Tomasz Kameczura, Katarzyna Wróbel, Danuta Czarnecka, Krystian Gruszka, Artur Jurczyszyn, Marek Rajzer, Tomasz Dróżdż, Małgorzata Wach-Pizoń, Wiktoria Wojciechowska, T. Pizon, Janusz Kąkol, Marta Rojek |
---|---|
Rok vydání: | 2018 |
Předmět: |
Adult
Male Arterial hypertension medicine.medical_specialty Medicine (General) arterial hypertension aldosterone-to-renin ratio Blood lipids 030204 cardiovascular system & hematology Plasma renin activity 03 medical and health sciences chemistry.chemical_compound plasma renin activity 0302 clinical medicine Endocrinology R5-920 Internal medicine Renin Internal Medicine medicine Humans In patient 030212 general & internal medicine Aged Aldosterone Primary (chemistry) aldosterone Aldosterone-to-renin ratio business.industry Middle Aged Lipids serum lipids chemistry Hypertension Multivariate Analysis Regression Analysis Female Original Article business |
Zdroj: | Journal of the Renin-Angiotensin-Aldosterone System: JRAAS Journal of the Renin-Angiotensin-Aldosterone System, Vol 19 (2018) |
ISSN: | 1752-8976 |
Popis: | Introduction: The aim of the study was to evaluate clinical and biochemical differences between patients with low-renin and high-renin primary arterial hypertension (AH), mainly in reference to serum lipids, and to identify factors determining lipid concentrations. Materials and methods: In untreated patients with AH stage 1 we measured plasma renin activity (PRA) and subdivided the group into low-renin (PRA < 0.65 ng/mL/h) and high-renin (PRA ⩾ 0.65 ng/mL/h) AH. We compared office and 24-h ambulatory blood pressure, serum aldosterone, lipids and selected biochemical parameters between subgroups. Factors determining lipid concentration in both subgroups were assessed in regression analysis. Results: Patients with high-renin hypertension ( N = 58) were characterized by higher heart rate ( p = 0.04), lower serum sodium ( p < 0.01) and aldosterone-to-renin ratio ( p < 0.01), and significantly higher serum aldosterone ( p = 0.03), albumin ( p < 0.01), total protein ( p < 0.01), total cholesterol ( p = 0.01) and low-density lipoprotein cholesterol (LDL-C) ( p = 0.04) than low-renin subjects ( N = 39). In univariate linear regression, only PRA in the low-renin group was in a positive relationship with LDL-C ( R2 = 0.15, β = 1.53 and p = 0.013); this association remained significant after adjustment for age, sex, and serum albumin and aldosterone concentrations. Conclusions: Higher serum levels of total and LDL-C characterized high-renin subjects, but the association between LDL-C level and PRA existed only in low-renin primary AH. |
Databáze: | OpenAIRE |
Externí odkaz: |