Performance of serum adenosine deaminase in measuring disease activity in rheumatoid arthritis patients
| Autor: | Tamer O. Elsaid, Abbed K.M. Hameed, Basma A. El-Kady, Hamdia Askar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
musculoskeletal diseases
lcsh:Immunologic diseases. Allergy medicine.medical_specialty Disease duration Disease Gastroenterology Disease activity 03 medical and health sciences 0302 clinical medicine Adenosine deaminase Rheumatology immune system diseases Internal medicine Medicine 030212 general & internal medicine skin and connective tissue diseases 030203 arthritis & rheumatology medicine.diagnostic_test biology business.industry Mean age medicine.disease Erythrocyte sedimentation rate Rheumatoid arthritis biology.protein business lcsh:RC581-607 |
| Zdroj: | Egyptian Rheumatologist, Vol 41, Iss 2, Pp 81-85 (2019) |
| ISSN: | 1110-1164 |
| Popis: | Background: Numerous tools to assess activity of rheumatoid arthritis (RA) are available to use. For any marker to be a more appropriate indicator of disease activity, it should be more authentic to the patho-physiologic basis of the disease. Aim of the work: To determine the performance of serum adenosine deaminase (sADA) in measuring disease activity in RA. Patients and Methods: 100 RA patients and 100 matched controls were included in the study. The disease activity score (DAS28) with erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were assessed. sADA level was determined by spectrophotometry. The sADA level was integrated in the DAS28 formulae and the corresponding values were determined. Results: The mean age of the RA patients was 61.8 ± 9.7 years, 68% were females and they had a disease duration of 12.5 ± 3.7 years. The mean DAS28-ESR was 4.2 ± 1.3 and DAS28-CRP 3.5 ± 1.1. The mean sADA was significantly higher in the patients (33.6 ± 11.6 U/L) compared to the control (25.1 ± 9.9 U/L) (p |
| Databáze: | OpenAIRE |
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